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alpha(2) Adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-Imidazo)-1,3-dimethyl-6,7-dihydrothianaphthene [corrected] as a high-affinity ligand for the alpha(2D) adrenergic receptor.
Ross TM, Jetter MC, McDonnell ME, Boyd RE, Connelly CD, Martinez RP, Lewis MA, Codd EE, Raffa RB, Reitz AB. Ross TM, et al. Among authors: jetter mc. J Med Chem. 2000 Mar 9;43(5):765-8. doi: 10.1021/jm990569e. J Med Chem. 2000. PMID: 10715142 Corrected and republished. No abstract available.
Alpha(2) adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-imidazo)-1,3-dimethyl-6,7-dihydro-thianaphthene as a high-affinity ligand for the alpha(2D) adrenergic receptor.
Ross TM, Jetter MC, McDonnell ME, Boyd RE, Connelly CD, Martinez RP, Lewis MA, Codd EE, Raffa RB, Reitz AB. Ross TM, et al. Among authors: jetter mc. J Med Chem. 2000 Apr 6;43(7):1423-6. doi: 10.1021/jm000128r. J Med Chem. 2000. PMID: 10753480 No abstract available.
Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist.
Swanson DM, Dubin AE, Shah C, Nasser N, Chang L, Dax SL, Jetter M, Breitenbucher JG, Liu C, Mazur C, Lord B, Gonzales L, Hoey K, Rizzolio M, Bogenstaetter M, Codd EE, Lee DH, Zhang SP, Chaplan SR, Carruthers NI. Swanson DM, et al. J Med Chem. 2005 Mar 24;48(6):1857-72. doi: 10.1021/jm0495071. J Med Chem. 2005. PMID: 15771431
Heteroaryl beta-tetralin ureas as novel antagonists of human TRPV1.
Jetter MC, Youngman MA, McNally JJ, McDonnell ME, Zhang SP, Dubin AE, Nasser N, Codd EE, Flores CM, Dax SL. Jetter MC, et al. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6160-3. doi: 10.1016/j.bmcl.2007.09.036. Epub 2007 Sep 12. Bioorg Med Chem Lett. 2007. PMID: 17892935