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Design and development of selective muscarinic agonists for the treatment of Alzheimer's disease: characterization of tetrahydropyrimidine derivatives and development of new approaches for improved affinity and selectivity for M1 receptors.
Messer WS Jr, Rajeswaran WG, Cao Y, Zhang HJ, el-Assadi AA, Dockery C, Liske J, O'Brien J, Williams FE, Huang XP, Wroblewski ME, Nagy PI, Peseckis SM. Messer WS Jr, et al. Among authors: el assadi aa. Pharm Acta Helv. 2000 Mar;74(2-3):135-40. doi: 10.1016/s0031-6865(99)00026-6. Pharm Acta Helv. 2000. PMID: 10812950
Design, synthesis, and neurochemical evaluation of 2-amino-5-(alkoxycarbonyl)-3,4,5,6-tetrahydropyridines and 2-amino-5-(alkoxycarbonyl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists.
Dunbar PG, Durant GJ, Rho T, Ojo B, Huzl JJ 3rd, Smith DA, el-Assadi AA, Sbeih S, Ngur DO, Periyasamy S, et al. Dunbar PG, et al. Among authors: el assadi aa. J Med Chem. 1994 Aug 19;37(17):2774-82. doi: 10.1021/jm00043a016. J Med Chem. 1994. PMID: 8064804
Synthesis and CLOGP correlation of imidooxy anticonvulsants.
Farrar VA, Ciechanowicz-Rutkowska M, Grochowski J, Serda P, Pilati T, Filippini G, Hinko CN, el-Assadi A, Moore JA, Edafiogho IO, et al. Farrar VA, et al. J Med Chem. 1993 Nov 12;36(23):3517-25. doi: 10.1021/jm00075a005. J Med Chem. 1993. PMID: 8246220