Chabin RM - Search Results

1

Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.

Hagmann WK, Caldwell CG, Chen P, Durette PL, Esser CK, Lanza TJ, Kopka IE, Guthikonda R, Shah SK, MacCoss M, Chabin RM, Fletcher D, Grant SK, Green BG, Humes JL, Kelly TM, Luell S, Meurer R, Moore V, Pacholok SG, Pavia T, Williams HR, Wong KK. Hagmann WK, et al. Among authors: chabin rm. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1975-8. doi: 10.1016/s0960-894x(00)00389-9. Bioorg Med Chem Lett. 2000. PMID: 10987430

2

Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inhibitors of inducible nitric oxide synthase.

Guthikonda RN, Shah SK, Pacholok SG, Humes JL, Mumford RA, Grant SK, Chabin RM, Green BG, Tsou N, Ball R, Fletcher DS, Luell S, Euan MacIntyre D, Maccoss M. Guthikonda RN, et al. Among authors: chabin rm. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1997-2001. doi: 10.1016/j.bmcl.2005.02.067. Bioorg Med Chem Lett. 2005. PMID: 15808455

3

The natural product noformycin is an inhibitor of inducible-nitric oxide synthase.

Green BG, Chabin R, Grant SK. Green BG, et al. Biochem Biophys Res Commun. 1996 Aug 14;225(2):621-6. doi: 10.1006/bbrc.1996.1220. Biochem Biophys Res Commun. 1996. PMID: 8753809

4

Inhibitors of the bacterial cell wall biosynthesis enzyme MurD.

Gegnas LD, Waddell ST, Chabin RM, Reddy S, Wong KK. Gegnas LD, et al. Among authors: chabin rm. Bioorg Med Chem Lett. 1998 Jul 7;8(13):1643-8. doi: 10.1016/s0960-894x(98)00285-6. Bioorg Med Chem Lett. 1998. PMID: 9873406

5

Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity.

Zhou C, Garcia-Calvo M, Pinto S, Lombardo M, Feng Z, Bender K, Pryor KD, Bhatt UR, Chabin RM, Geissler WM, Shen Z, Tong X, Zhang Z, Wong KK, Roy RS, Chapman KT, Yang L, Xiong Y. Zhou C, et al. Among authors: chabin rm. J Med Chem. 2010 Oct 14;53(19):7251-63. doi: 10.1021/jm101013m. J Med Chem. 2010. PMID: 20857914

6

Active-site structure analysis of recombinant human inducible nitric oxide synthase using imidazole.

Chabin RM, McCauley E, Calaycay JR, Kelly TM, MacNaul KL, Wolfe GC, Hutchinson NI, Madhusudanaraju S, Schmidt JA, Kozarich JW, Wong KK. Chabin RM, et al. Biochemistry. 1996 Jul 23;35(29):9567-75. doi: 10.1021/bi960476o. Biochemistry. 1996. PMID: 8755738

7

Mechanism of inhibition of human leucocyte elastase by monocyclic beta-lactams.

Chabin R, Green BG, Gale P, Maycock AL, Weston H, Dorn CP, Finke PE, Hagmann WK, Hale JJ, MacCoss M, et al. Chabin R, et al. Biochemistry. 1993 Aug 31;32(34):8970-80. doi: 10.1021/bi00085a031. Biochemistry. 1993. PMID: 8364042

8

Inhibition of human serine proteases by substituted 2-azetidinones.

Knight WB, Chabin R, Green B. Knight WB, et al. Arch Biochem Biophys. 1992 Aug 1;296(2):704-8. doi: 10.1016/0003-9861(92)90630-f. Arch Biochem Biophys. 1992. PMID: 1632655

9

Specificity, stability, and potency of monocyclic beta-lactam inhibitors of human leucocyte elastase.

Knight WB, Green BG, Chabin RM, Gale P, Maycock AL, Weston H, Kuo DW, Westler WM, Dorn CP, Finke PE, et al. Knight WB, et al. Among authors: chabin rm. Biochemistry. 1992 Sep 8;31(35):8160-70. doi: 10.1021/bi00150a007. Biochemistry. 1992. PMID: 1525156

10

Mechanism of inhibition of human leucocyte elastase by beta-lactams. 3. Use of electrospray ionization mass spectrometry and two-dimensional NMR techniques to identify beta-lactam-derived E-I complexes.

Underwood DJ, Green BG, Chabin R, Mills S, Doherty JB, Finke PE, MacCoss M, Shah SK, Burgey CS, Dickinson TA, et al. Underwood DJ, et al. Biochemistry. 1995 Nov 7;34(44):14344-55. doi: 10.1021/bi00044a011. Biochemistry. 1995. PMID: 7578038

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