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A multicenter, randomized, double-blind, placebo-controlled, 8-week trial of the efficacy and tolerability of once-daily losartan 100 mg/hydrochlorothiazide 25 mg and losartan 50 mg/hydrochlorothiazide 12.5 mg in the treatment of moderate-to-severe essential hypertension.
Gradman AH, Brady WE, Gazdick LP, Lyle P, Zeldin RK. Gradman AH, et al. Among authors: gazdick lp. Clin Ther. 2002 Jul;24(7):1049-61. doi: 10.1016/s0149-2918(02)80018-2. Clin Ther. 2002. PMID: 12182251 Clinical Trial.