Halpin RA - Search Results

1

The absorption, distribution, metabolism and excretion of rofecoxib, a potent and selective cyclooxygenase-2 inhibitor, in rats and dogs.

Halpin RA, Geer LA, Zhang KE, Marks TM, Dean DC, Jones AN, Melillo D, Doss G, Vyas KP. Halpin RA, et al. Drug Metab Dispos. 2000 Oct;28(10):1244-54. Drug Metab Dispos. 2000. PMID: 10997947

2

The disposition and metabolism of rofecoxib, a potent and selective cyclooxygenase-2 inhibitor, in human subjects.

Halpin RA, Porras AG, Geer LA, Davis MR, Cui D, Doss GA, Woolf E, Musson D, Matthews C, Mazenko R, Schwartz JI, Lasseter KC, Vyas KP, Baillie TA. Halpin RA, et al. Drug Metab Dispos. 2002 Jun;30(6):684-93. doi: 10.1124/dmd.30.6.684. Drug Metab Dispos. 2002. PMID: 12019196

3

Absorption, metabolism, and excretion of etoricoxib, a potent and selective cyclooxygenase-2 inhibitor, in healthy male volunteers.

Rodrigues AD, Halpin RA, Geer LA, Cui D, Woolf EJ, Matthews CZ, Gottesdiener KM, Larson PJ, Lasseter KC, Agrawal NG. Rodrigues AD, et al. Among authors: halpin ra. Drug Metab Dispos. 2003 Feb;31(2):224-32. doi: 10.1124/dmd.31.2.224. Drug Metab Dispos. 2003. PMID: 12527704

4

Metabolism of rofecoxib in vitro using human liver subcellular fractions.

Slaughter D, Takenaga N, Lu P, Assang C, Walsh DJ, Arison BH, Cui D, Halpin RA, Geer LA, Vyas KP, Baillie TA. Slaughter D, et al. Among authors: halpin ra. Drug Metab Dispos. 2003 Nov;31(11):1398-408. doi: 10.1124/dmd.31.11.1398. Drug Metab Dispos. 2003. PMID: 14570773

5

Biotransformation of lovastatin. V. Species differences in in vivo metabolite profiles of mouse, rat, dog, and human.

Halpin RA, Ulm EH, Till AE, Kari PH, Vyas KP, Hunninghake DB, Duggan DE. Halpin RA, et al. Drug Metab Dispos. 1993 Nov-Dec;21(6):1003-11. Drug Metab Dispos. 1993. PMID: 7905377

6

Disposition and pharmacokinetics of the antimigraine drug, rizatriptan, in humans.

Vyas KP, Halpin RA, Geer LA, Ellis JD, Liu L, Cheng H, Chavez-Eng C, Matuszewski BK, Varga SL, Guiblin AR, Rogers JD. Vyas KP, et al. Among authors: halpin ra. Drug Metab Dispos. 2000 Jan;28(1):89-95. Drug Metab Dispos. 2000. PMID: 10611145

7

Role of human liver cytochrome P4503A in the metabolism of etoricoxib, a novel cyclooxygenase-2 selective inhibitor.

Kassahun K, McIntosh IS, Shou M, Walsh DJ, Rodeheffer C, Slaughter DE, Geer LA, Halpin RA, Agrawal N, Rodrigues AD. Kassahun K, et al. Among authors: halpin ra. Drug Metab Dispos. 2001 Jun;29(6):813-20. Drug Metab Dispos. 2001. PMID: 11353749

8

Mechanistic studies on the reversible metabolism of rofecoxib to 5-hydroxyrofecoxib in the rat: evidence for transient ring opening of a substituted 2-furanone derivative using stable isotope-labeling techniques.

Baillie TA, Halpin RA, Matuszewski BK, Geer LA, Chavez-Eng CM, Dean D, Braun M, Doss G, Jones A, Marks T, Melillo D, Vyas KP. Baillie TA, et al. Among authors: halpin ra. Drug Metab Dispos. 2001 Dec;29(12):1614-28. Drug Metab Dispos. 2001. PMID: 11717181

9

Biotransformation of lovastatin. I. Structure elucidation of in vitro and in vivo metabolites in the rat and mouse.

Vyas KP, Kari PH, Pitzenberger SM, Halpin RA, Ramjit HG, Arison B, Murphy JS, Hoffman WF, Schwartz MS, Ulm EH, et al. Vyas KP, et al. Among authors: halpin ra. Drug Metab Dispos. 1990 Mar-Apr;18(2):203-11. Drug Metab Dispos. 1990. PMID: 1971574

10

Influence of beta-adrenoceptor antagonists on the pharmacokinetics of rizatriptan, a 5-HT1B/1D agonist: differential effects of propranolol, nadolol and metoprolol.

Goldberg MR, Sciberras D, De Smet M, Lowry R, Tomasko L, Lee Y, Olah TV, Zhao J, Vyas KP, Halpin R, Kari PH, James I. Goldberg MR, et al. Br J Clin Pharmacol. 2001 Jul;52(1):69-76. doi: 10.1046/j.0306-5251.2001.01417.x. Br J Clin Pharmacol. 2001. PMID: 11453892 Free PMC article. Clinical Trial.

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