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Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus.
Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, Hinokio Y, Lindner TH, Mashima H, Schwarz PE, del Bosque-Plata L, Horikawa Y, Oda Y, Yoshiuchi I, Colilla S, Polonsky KS, Wei S, Concannon P, Iwasaki N, Schulze J, Baier LJ, Bogardus C, Groop L, Boerwinkle E, Hanis CL, Bell GI. Horikawa Y, et al. Among authors: polonsky ks. Nat Genet. 2000 Oct;26(2):163-75. doi: 10.1038/79876. Nat Genet. 2000. PMID: 11017071
Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3).
Yamagata K, Oda N, Kaisaki PJ, Menzel S, Furuta H, Vaxillaire M, Southam L, Cox RD, Lathrop GM, Boriraj VV, Chen X, Cox NJ, Oda Y, Yano H, Le Beau MM, Yamada S, Nishigori H, Takeda J, Fajans SS, Hattersley AT, Iwasaki N, Hansen T, Pedersen O, Polonsky KS, Bell GI, et al. Yamagata K, et al. Among authors: polonsky ks. Nature. 1996 Dec 5;384(6608):455-8. doi: 10.1038/384455a0. Nature. 1996. PMID: 8945470 Free article.
Calpains play a role in insulin secretion and action.
Sreenan SK, Zhou YP, Otani K, Hansen PA, Currie KP, Pan CY, Lee JP, Ostrega DM, Pugh W, Horikawa Y, Cox NJ, Hanis CL, Burant CF, Fox AP, Bell GI, Polonsky KS. Sreenan SK, et al. Among authors: polonsky ks. Diabetes. 2001 Sep;50(9):2013-20. doi: 10.2337/diabetes.50.9.2013. Diabetes. 2001. PMID: 11522666
Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome.
Kawai T, Ng MC, Hayes MG, Yoshiuchi I, Tsuchiya T, Robertson H, Cox NJ, Polonsky KS, Bell GI, Ehrmann DA. Kawai T, et al. Among authors: polonsky ks. Diabetes Res Clin Pract. 2009 Dec;86(3):186-92. doi: 10.1016/j.diabres.2009.09.002. Epub 2009 Sep 25. Diabetes Res Clin Pract. 2009. PMID: 19782423 Free PMC article.
Organ alchemy: producing insulin in the liver.
Polonsky KS, Bell GI. Polonsky KS, et al. Nat Med. 2003 May;9(5):504-5. doi: 10.1038/nm0503-504. Nat Med. 2003. PMID: 12724755 No abstract available.
286 results