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A major susceptibility locus for atopic dermatitis maps to chromosome 3q21.
Lee YA, Wahn U, Kehrt R, Tarani L, Businco L, Gustafsson D, Andersson F, Oranje AP, Wolkertstorfer A, v Berg A, Hoffmann U, Küster W, Wienker T, Rüschendorf F, Reis A. Lee YA, et al. Among authors: v berg a. Nat Genet. 2000 Dec;26(4):470-3. doi: 10.1038/82625. Nat Genet. 2000. PMID: 11101848
The hygiene hypothesis does not apply to atopic eczema in childhood.
Cramer C, Link E, Koletzko S, Lehmann I, Heinrich J, Wichmann HE, Bauer CP, V Berg A, Berdel D, Herbarth O, Schaaf B, Borte M, Behrendt H, Krämer U. Cramer C, et al. Among authors: v berg a. Chem Immunol Allergy. 2012;96:15-23. doi: 10.1159/000331805. Epub 2012 Mar 13. Chem Immunol Allergy. 2012. PMID: 22433366