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Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity.
Gisselsson D, Pettersson L, Höglund M, Heidenblad M, Gorunova L, Wiegant J, Mertens F, Dal Cin P, Mitelman F, Mandahl N. Gisselsson D, et al. Among authors: heidenblad m. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5357-62. doi: 10.1073/pnas.090013497. Proc Natl Acad Sci U S A. 2000. PMID: 10805796 Free PMC article.
Combined high-resolution array-based comparative genomic hybridization and expression profiling of ETV6/RUNX1-positive acute lymphoblastic leukemias reveal a high incidence of cryptic Xq duplications and identify several putative target genes within the commonly gained region.
Lilljebjörn H, Heidenblad M, Nilsson B, Lassen C, Horvat A, Heldrup J, Behrendtz M, Johansson B, Andersson A, Fioretos T. Lilljebjörn H, et al. Among authors: heidenblad m. Leukemia. 2007 Oct;21(10):2137-44. doi: 10.1038/sj.leu.2404879. Epub 2007 Aug 9. Leukemia. 2007. PMID: 17690704
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