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Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy.
Patel R, Nagueh SF, Tsybouleva N, Abdellatif M, Lutucuta S, Kopelen HA, Quinones MA, Zoghbi WA, Entman ML, Roberts R, Marian AJ. Patel R, et al. Among authors: tsybouleva n. Circulation. 2001 Jul 17;104(3):317-24. doi: 10.1161/hc2801.094031. Circulation. 2001. PMID: 11457751 Free PMC article.
Evolution of expression of cardiac phenotypes over a 4-year period in the beta-myosin heavy chain-Q403 transgenic rabbit model of human hypertrophic cardiomyopathy.
Nagueh SF, Chen S, Patel R, Tsybouleva N, Lutucuta S, Kopelen HA, Zoghbi WA, Quiñones MA, Roberts R, Marian AJ. Nagueh SF, et al. Among authors: tsybouleva n. J Mol Cell Cardiol. 2004 May;36(5):663-73. doi: 10.1016/j.yjmcc.2004.02.010. J Mol Cell Cardiol. 2004. PMID: 15135661 Free PMC article.
Aldosterone, through novel signaling proteins, is a fundamental molecular bridge between the genetic defect and the cardiac phenotype of hypertrophic cardiomyopathy.
Tsybouleva N, Zhang L, Chen S, Patel R, Lutucuta S, Nemoto S, DeFreitas G, Entman M, Carabello BA, Roberts R, Marian AJ. Tsybouleva N, et al. Circulation. 2004 Mar 16;109(10):1284-91. doi: 10.1161/01.CIR.0000121426.43044.2B. Epub 2004 Mar 1. Circulation. 2004. PMID: 14993121 Free PMC article.