Tolman RL - Search Results

1

Design and synthesis of novel antibacterial agents with inhibitory activity against DNA polymerase III.

Ali A, Aster SD, Graham DW, Patel GF, Taylor GE, Tolman RL, Painter RE, Silver LL, Young K, Ellsworth K, Geissler W, Harris GS. Ali A, et al. Among authors: tolman rl. Bioorg Med Chem Lett. 2001 Aug 20;11(16):2185-8. doi: 10.1016/s0960-894x(01)00407-3. Bioorg Med Chem Lett. 2001. PMID: 11514166

2

4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase.

Bakshi RK, Patel GF, Rasmusson GH, Baginsky WF, Cimis G, Ellsworth K, Chang B, Bull H, Tolman RL, Harris GS. Bakshi RK, et al. Among authors: tolman rl. J Med Chem. 1994 Nov 11;37(23):3871-4. doi: 10.1021/jm00049a003. J Med Chem. 1994. PMID: 7966146 No abstract available.

3

4-Aza-3-oxo-5 alpha-androst-1-ene-17 beta-N-aryl-carboxamides as dual inhibitors of human type 1 and type 2 steroid 5 alpha-reductases. Dramatic effect of N-aryl substituents on type 1 and type 2 5 alpha-reductase inhibitory potency.

Bakshi RK, Rasmusson GH, Patel GF, Mosley RT, Chang B, Ellsworth K, Harris GS, Tolman RL. Bakshi RK, et al. Among authors: tolman rl. J Med Chem. 1995 Aug 18;38(17):3189-92. doi: 10.1021/jm00017a001. J Med Chem. 1995. PMID: 7650670 No abstract available.

4

4-Methyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-N-aryl-carboxamides: an approach to combined androgen blockade [5alpha-reductase inhibition with androgen receptor binding in vitro].

Tolman RL, Sahoo SP, Bakshi RK, Gratale D, Patel G, Patel S, Toney J, Chang B, Harris GS. Tolman RL, et al. J Steroid Biochem Mol Biol. 1997 Mar;60(5-6):303-9. doi: 10.1016/s0960-0760(96)00199-9. J Steroid Biochem Mol Biol. 1997. PMID: 9219921

5

Inhibitors of folate biosynthesis. 1. Inhibition of dihydroneopterin aldolase by pteridine derivatives.

Zimmerman M, Tolman RL, Morman H, Graham DW, Rogers EF. Zimmerman M, et al. Among authors: tolman rl. J Med Chem. 1977 Sep;20(9):1213-5. doi: 10.1021/jm00219a021. J Med Chem. 1977. PMID: 336889

6

MK386: a potent, selective inhibitor of the human type 1 5alpha-reductase.

Ellsworth K, Azzolina B, Baginsky W, Bull H, Chang B, Cimis G, Mitra S, Toney J, Bakshi RK, Rasmusson GR, Tolman RL, Harris GS. Ellsworth K, et al. Among authors: tolman rl. J Steroid Biochem Mol Biol. 1996 Jul;58(4):377-84. doi: 10.1016/0960-0760(96)00050-7. J Steroid Biochem Mol Biol. 1996. PMID: 8903421

7

Identification and selective inhibition of an isozyme of steroid 5 alpha-reductase in human scalp.

Harris G, Azzolina B, Baginsky W, Cimis G, Rasmusson GH, Tolman RL, Raetz CR, Ellsworth K. Harris G, et al. Among authors: tolman rl. Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10787-91. doi: 10.1073/pnas.89.22.10787. Proc Natl Acad Sci U S A. 1992. PMID: 1438277 Free PMC article.

8

Synthesis and hypoglycemic activity of substituted 8-(1-piperazinyl)imidazo[1,2-a]pyrazines.

Meurer LC, Tolman RL, Chapin EW, Saperstein R, Vicario PP, Zrada MM, MacCoss M. Meurer LC, et al. Among authors: tolman rl. J Med Chem. 1992 Oct 16;35(21):3845-57. doi: 10.1021/jm00099a012. J Med Chem. 1992. PMID: 1359141

9

5-Aryl thiazolidine-2,4-diones as selective PPARgamma agonists.

Koyama H, Boueres JK, Han W, Metzger EJ, Bergman JP, Gratale DF, Miller DJ, Tolman RL, MacNaul KL, Berger JP, Doebber TW, Leung K, Moller DE, Heck JV, Sahoo SP. Koyama H, et al. Among authors: tolman rl. Bioorg Med Chem Lett. 2003 May 19;13(10):1801-4. doi: 10.1016/s0960-894x(03)00257-9. Bioorg Med Chem Lett. 2003. PMID: 12729668

10

Renin inhibitors containing C-termini derived from mercaptoheterocycles.

Ashton WT, Cantone CL, Meurer LC, Tolman RL, Greenlee WJ, Patchett AA, Lynch RJ, Schorn TW, Strouse JF, Siegl PK. Ashton WT, et al. Among authors: tolman rl. J Med Chem. 1992 May 29;35(11):2103-12. doi: 10.1021/jm00089a023. J Med Chem. 1992. PMID: 1597860

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