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Farnesyl: proteintransferase inhibitors as agents to inhibit tumor growth.
Omer CA, Anthony NJ, Buser-Doepner CA, Burkhardt AL, deSolms SJ, Dinsmore CJ, Gibbs JB, Hartman GD, Koblan KS, Lobell RB, Oliff A, Williams TM, Kohl NE. Omer CA, et al. Among authors: dinsmore cj. Biofactors. 1997;6(3):359-66. doi: 10.1002/biof.5520060306. Biofactors. 1997. PMID: 9288406 Review.
Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.
Lobell RB, Omer CA, Abrams MT, Bhimnathwala HG, Brucker MJ, Buser CA, Davide JP, deSolms SJ, Dinsmore CJ, Ellis-Hutchings MS, Kral AM, Liu D, Lumma WC, Machotka SV, Rands E, Williams TM, Graham SL, Hartman GD, Oliff AI, Heimbrook DC, Kohl NE. Lobell RB, et al. Among authors: dinsmore cj. Cancer Res. 2001 Dec 15;61(24):8758-68. Cancer Res. 2001. PMID: 11751396
Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase.
Ciccarone TM, MacTough SC, Williams TM, Dinsmore CJ, O'Neill TJ, Shah D, Culberson JC, Koblan KS, Kohl NE, Gibbs JB, Oliff AI, Graham SL, Hartman GD. Ciccarone TM, et al. Among authors: dinsmore cj. Bioorg Med Chem Lett. 1999 Jul 19;9(14):1991-6. doi: 10.1016/s0960-894x(99)00323-6. Bioorg Med Chem Lett. 1999. PMID: 10450968
Anions modulate the potency of geranylgeranyl-protein transferase I inhibitors.
Huber HE, Robinson RG, Watkins A, Nahas DD, Abrams MT, Buser CA, Lobell RB, Patrick D, Anthony NJ, Dinsmore CJ, Graham SL, Hartman GD, Lumma WC, Williams TM, Heimbrook DC. Huber HE, et al. Among authors: dinsmore cj. J Biol Chem. 2001 Jul 6;276(27):24457-65. doi: 10.1074/jbc.M100325200. Epub 2001 Mar 26. J Biol Chem. 2001. PMID: 11274181 Free article.
2-Arylindole-3-acetamides: FPP-competitive inhibitors of farnesyl protein transferase.
Trotter BW, Quigley AG, Lumma WC, Sisko JT, Walsh ES, Hamann CS, Robinson RG, Bhimnathwala H, Kolodin DG, Zheng W, Buser CA, Huber HE, Lobell RB, Kohl NE, Williams TM, Graham SL, Dinsmore CJ. Trotter BW, et al. Among authors: dinsmore cj. Bioorg Med Chem Lett. 2001 Apr 9;11(7):865-9. doi: 10.1016/s0960-894x(01)00061-0. Bioorg Med Chem Lett. 2001. PMID: 11294379
Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferase.
Beshore DC, Bell IM, Dinsmore CJ, Homnick CF, Culberson JC, Robinson RG, Fernandes C, Walsh ES, Abrams MT, Bhimnathwala HG, Davide JP, Ellis-Hutchings MS, Huber HA, Koblan KS, Buser CA, Kohl NE, Lobell RB, Chen IW, McLoughlin DA, Olah TV, Graham SL, Hartman GD, Williams TM. Beshore DC, et al. Among authors: dinsmore cj. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1817-21. doi: 10.1016/s0960-894x(01)00340-7. Bioorg Med Chem Lett. 2001. PMID: 11459639
52 results