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Liquid chromatographic-tandem mass spectrometric urine assay for a highly metabolized cyclic ureidobenzenesulfonamide: issues concerning assay specificity and quality control preparation.
Fisher AL, DePuy E, Shih T, Stearns R, Lee Y, Gottesdiener K, Flattery S, De Smet M, Keymeulen B, Musson DG. Fisher AL, et al. Among authors: de smet m. J Pharm Biomed Anal. 2001 Dec;26(5-6):739-52. doi: 10.1016/s0731-7085(01)00438-1. J Pharm Biomed Anal. 2001. PMID: 11600286
The effect of rofecoxib on the pharmacodynamics and pharmcokinetics of warfarin.
Schwartz JI, Bugianesi KJ, Ebel DL, De Smet M, Haesen R, Larson PJ, Ko A, Verbesselt R, Hunt TL, Lins R, Lens S, Porras AG, Dieck J, Keymeulen B, Gertz BJ. Schwartz JI, et al. Among authors: de smet m. Clin Pharmacol Ther. 2000 Dec;68(6):626-36. doi: 10.1067/mcp.2000.112244. Clin Pharmacol Ther. 2000. PMID: 11180023 Clinical Trial.
Influence of beta-adrenoceptor antagonists on the pharmacokinetics of rizatriptan, a 5-HT1B/1D agonist: differential effects of propranolol, nadolol and metoprolol.
Goldberg MR, Sciberras D, De Smet M, Lowry R, Tomasko L, Lee Y, Olah TV, Zhao J, Vyas KP, Halpin R, Kari PH, James I. Goldberg MR, et al. Among authors: de smet m. Br J Clin Pharmacol. 2001 Jul;52(1):69-76. doi: 10.1046/j.0306-5251.2001.01417.x. Br J Clin Pharmacol. 2001. PMID: 11453892 Free PMC article. Clinical Trial.
Safety, tolerability, and pharmacokinetics of raltegravir after single and multiple doses in healthy subjects.
Iwamoto M, Wenning LA, Petry AS, Laethem M, De Smet M, Kost JT, Merschman SA, Strohmaier KM, Ramael S, Lasseter KC, Stone JA, Gottesdiener KM, Wagner JA. Iwamoto M, et al. Among authors: de smet m. Clin Pharmacol Ther. 2008 Feb;83(2):293-9. doi: 10.1038/sj.clpt.6100281. Epub 2007 Aug 22. Clin Pharmacol Ther. 2008. PMID: 17713476 Clinical Trial.
Multiple-dose pharmacodynamics and pharmacokinetics of anacetrapib, a potent cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects.
Krishna R, Bergman AJ, Jin B, Fallon M, Cote J, Van Hoydonck P, Laethem T, Gendrano IN 3rd, Van Dyck K, Hilliard D, Laterza O, Snyder K, Chavez-Eng C, Lutz R, Chen J, Bloomfield DM, De Smet M, Van Bortel LM, Gutierrez M, Al-Huniti N, Dykstra K, Gottesdiener KM, Wagner JA. Krishna R, et al. Among authors: de smet m. Clin Pharmacol Ther. 2008 Dec;84(6):679-83. doi: 10.1038/clpt.2008.109. Epub 2008 Jun 25. Clin Pharmacol Ther. 2008. PMID: 18580870 Clinical Trial. No abstract available.
Improving method capability of a drug substance HPLC assay.
Dejaegher B, Jimidar M, De Smet M, Cockaerts P, Smeyers-Verbeke J, Vander Heyden Y. Dejaegher B, et al. Among authors: de smet m. J Pharm Biomed Anal. 2006 Sep 18;42(2):155-70. doi: 10.1016/j.jpba.2006.01.001. Epub 2006 Apr 18. J Pharm Biomed Anal. 2006. PMID: 16621413
439 results