Evans DC - Search Results

1

Bioactivation of diclofenac via benzoquinone imine intermediates-identification of urinary mercapturic acid derivatives in rats and humans.

Poon GK, Chen Q, Teffera Y, Ngui JS, Griffin PR, Braun MP, Doss GA, Freeden C, Stearns RA, Evans DC, Baillie TA, Tang W. Poon GK, et al. Among authors: evans dc. Drug Metab Dispos. 2001 Dec;29(12):1608-13. Drug Metab Dispos. 2001. PMID: 11717180

2

Cytochrome P450 3A4-mediated bioactivation of raloxifene: irreversible enzyme inhibition and thiol adduct formation.

Chen Q, Ngui JS, Doss GA, Wang RW, Cai X, DiNinno FP, Blizzard TA, Hammond ML, Stearns RA, Evans DC, Baillie TA, Tang W. Chen Q, et al. Among authors: evans dc. Chem Res Toxicol. 2002 Jul;15(7):907-14. doi: 10.1021/tx0200109. Chem Res Toxicol. 2002. PMID: 12119000

3

Metabolic activation of fluoropyrrolidine dipeptidyl peptidase-IV inhibitors by rat liver microsomes.

Xu S, Zhu B, Teffera Y, Pan DE, Caldwell CG, Doss G, Stearns RA, Evans DC, Beconi MG. Xu S, et al. Among authors: evans dc. Drug Metab Dispos. 2005 Jan;33(1):121-30. doi: 10.1124/dmd.104.001842. Epub 2004 Oct 14. Drug Metab Dispos. 2005. PMID: 15486074

4

Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.

Chen Q, Doss GA, Tung EC, Liu W, Tang YS, Braun MP, Didolkar V, Strauss JR, Wang RW, Stearns RA, Evans DC, Baillie TA, Tang W. Chen Q, et al. Among authors: evans dc. Drug Metab Dispos. 2006 Jan;34(1):145-51. doi: 10.1124/dmd.105.004341. Epub 2005 Oct 26. Drug Metab Dispos. 2006. PMID: 16251255

5

Species differences in metabolism and pharmacokinetics of a sphingosine-1-phosphate receptor agonist in rats and dogs: formation of a unique glutathione adduct in the rat.

Anari MR, Creighton MD, Ngui JS, Tschirret-Guth RA, Teffera Y, Doss GA, Tang W, Yu NX, Ciccotto SL, Hobra DF Jr, Coleman JB, Vincent SH, Evans DC. Anari MR, et al. Among authors: evans dc. Drug Metab Dispos. 2006 Aug;34(8):1367-75. doi: 10.1124/dmd.105.009027. Epub 2006 May 12. Drug Metab Dispos. 2006. PMID: 16698892

6

Extrapolation of diclofenac clearance from in vitro microsomal metabolism data: role of acyl glucuronidation and sequential oxidative metabolism of the acyl glucuronide.

Kumar S, Samuel K, Subramanian R, Braun MP, Stearns RA, Chiu SH, Evans DC, Baillie TA. Kumar S, et al. Among authors: evans dc. J Pharmacol Exp Ther. 2002 Dec;303(3):969-78. doi: 10.1124/jpet.102.038992. J Pharmacol Exp Ther. 2002. PMID: 12438516

7

Addressing the metabolic activation potential of new leads in drug discovery: a case study using ion trap mass spectrometry and tritium labeling techniques.

Samuel K, Yin W, Stearns RA, Tang YS, Chaudhary AG, Jewell JP, Lanza T Jr, Lin LS, Hagmann WK, Evans DC, Kumar S. Samuel K, et al. Among authors: evans dc. J Mass Spectrom. 2003 Feb;38(2):211-21. doi: 10.1002/jms.434. J Mass Spectrom. 2003. PMID: 12577288

8

Validation of (-)-N-3-benzyl-phenobarbital as a selective inhibitor of CYP2C19 in human liver microsomes.

Cai X, Wang RW, Edom RW, Evans DC, Shou M, Rodrigues AD, Liu W, Dean DC, Baillie TA. Cai X, et al. Among authors: evans dc. Drug Metab Dispos. 2004 Jun;32(6):584-6. doi: 10.1124/dmd.32.6.584. Drug Metab Dispos. 2004. PMID: 15155548

9

Minimizing the potential for metabolic activation as an integral part of drug design.

Evans DC, Baillie TA. Evans DC, et al. Curr Opin Drug Discov Devel. 2005 Jan;8(1):44-50. Curr Opin Drug Discov Devel. 2005. PMID: 15679171 Review.

10

Metabolic activation of a 1,3-disubstituted piperazine derivative: evidence for a novel ring contraction to an imidazoline.

Doss GA, Miller RR, Zhang Z, Teffera Y, Nargund RP, Palucki B, Park MK, Tang YS, Evans DC, Baillie TA, Stearns RA. Doss GA, et al. Among authors: evans dc. Chem Res Toxicol. 2005 Feb;18(2):271-6. doi: 10.1021/tx049711r. Chem Res Toxicol. 2005. PMID: 15720132

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

314 results

Search Page