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Mechanistic studies on the reversible metabolism of rofecoxib to 5-hydroxyrofecoxib in the rat: evidence for transient ring opening of a substituted 2-furanone derivative using stable isotope-labeling techniques.
Baillie TA, Halpin RA, Matuszewski BK, Geer LA, Chavez-Eng CM, Dean D, Braun M, Doss G, Jones A, Marks T, Melillo D, Vyas KP. Baillie TA, et al. Among authors: geer la. Drug Metab Dispos. 2001 Dec;29(12):1614-28. Drug Metab Dispos. 2001. PMID: 11717181
Metabolism of rofecoxib in vitro using human liver subcellular fractions.
Slaughter D, Takenaga N, Lu P, Assang C, Walsh DJ, Arison BH, Cui D, Halpin RA, Geer LA, Vyas KP, Baillie TA. Slaughter D, et al. Among authors: geer la. Drug Metab Dispos. 2003 Nov;31(11):1398-408. doi: 10.1124/dmd.31.11.1398. Drug Metab Dispos. 2003. PMID: 14570773
Pharmacokinetics of etoricoxib in patients with renal impairment.
Agrawal NG, Matthews CZ, Mazenko RS, Kline WF, Woolf EJ, Porras AG, Geer LA, Wong PH, Cho M, Cote J, Marbury TC, Moncrief JW, Alcorn H Jr, Swan S, Sack MR, Robson RA, Petty KJ, Schwartz JI, Gottesdiener KM. Agrawal NG, et al. Among authors: geer la. J Clin Pharmacol. 2004 Jan;44(1):48-58. doi: 10.1177/0091270003260338. J Clin Pharmacol. 2004. PMID: 14681341
Pharmacokinetics of etoricoxib in patients with hepatic impairment.
Agrawal NG, Rose MJ, Matthews CZ, Woolf EJ, Porras AG, Geer LA, Larson PJ, Cote J, Dilzer SC, Lasseter KC, Alam I, Petty KJ, Gottesdiener KM. Agrawal NG, et al. Among authors: geer la. J Clin Pharmacol. 2003 Oct;43(10):1136-48. doi: 10.1177/0091270003257219. J Clin Pharmacol. 2003. PMID: 14517196 Clinical Trial.
32 results