Bohacek RS - Search Results

1

Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design.

Greenspan PD, Clark KL, Tommasi RA, Cowen SD, McQuire LW, Farley DL, van Duzer JH, Goldberg RL, Zhou H, Du Z, Fitt JJ, Coppa DE, Fang Z, Macchia W, Zhu L, Capparelli MP, Goldstein R, Wigg AM, Doughty JR, Bohacek RS, Knap AK. Greenspan PD, et al. Among authors: bohacek rs. J Med Chem. 2001 Dec 20;44(26):4524-34. doi: 10.1021/jm010206q. J Med Chem. 2001. PMID: 11741472

2

Design and synthesis of an orally active macrocyclic neutral endopeptidase 24.11 inhibitor.

MacPherson LJ, Bayburt EK, Capparelli MP, Bohacek RS, Clarke FH, Ghai RD, Sakane Y, Berry CJ, Peppard JV, Trapani AJ. MacPherson LJ, et al. Among authors: bohacek rs. J Med Chem. 1993 Nov 26;36(24):3821-8. doi: 10.1021/jm00076a009. J Med Chem. 1993. PMID: 8254611

3

Ortho-substituted benzofused macrocyclic lactams as zinc metalloprotease inhibitors.

Ksander GM, de Jesus R, Yuan A, Ghai RD, Trapani A, McMartin C, Bohacek R. Ksander GM, et al. J Med Chem. 1997 Feb 14;40(4):495-505. doi: 10.1021/jm960582o. J Med Chem. 1997. PMID: 9046340

4

Meta-substituted benzofused macrocyclic lactams as zinc metalloprotease inhibitors.

Ksander GM, de Jesus R, Yuan A, Ghai RD, McMartin C, Bohacek R. Ksander GM, et al. J Med Chem. 1997 Feb 14;40(4):506-14. doi: 10.1021/jm960583g. J Med Chem. 1997. PMID: 9046341

5

Structure-based design and synthesis of a novel class of Src SH2 inhibitors.

Buchanan JL, Bohacek RS, Luke GP, Hatada M, Lu X, Dalgarno DC, Narula SS, Yuan R, Holt DA. Buchanan JL, et al. Among authors: bohacek rs. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2353-8. doi: 10.1016/s0960-894x(99)00388-1. Bioorg Med Chem Lett. 1999. PMID: 10476868

6

The art and practice of structure-based drug design: a molecular modeling perspective.

Bohacek RS, McMartin C, Guida WC. Bohacek RS, et al. Med Res Rev. 1996 Jan;16(1):3-50. doi: 10.1002/(SICI)1098-1128(199601)16:1<3::AID-MED1>3.0.CO;2-6. Med Res Rev. 1996. PMID: 8788213 Review. No abstract available.

7

Discovery of potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70.

Vu CB, Corpuz EG, Merry TJ, Pradeepan SG, Bartlett C, Bohacek RS, Botfield MC, Eyermann CJ, Lynch BA, MacNeil IA, Ram MK, van Schravendijk MR, Violette S, Sawyer TK. Vu CB, et al. Among authors: bohacek rs. J Med Chem. 1999 Oct 7;42(20):4088-98. doi: 10.1021/jm990229t. J Med Chem. 1999. PMID: 10514279

8

Structure-based design of novel bicyclic nonpeptide inhibitors for the src SH2 domain.

Shakespeare WC, Bohacek RS, Azimioara MD, Macek KJ, Luke GP, Dalgarno DC, Hatada MH, Lu X, Violette SM, Bartlett C, Sawyer TK. Shakespeare WC, et al. Among authors: bohacek rs. J Med Chem. 2000 Oct 19;43(21):3815-9. doi: 10.1021/jm0003337. J Med Chem. 2000. PMID: 11052784 No abstract available.

9

Definition and display of steric, hydrophobic, and hydrogen-bonding properties of ligand binding sites in proteins using Lee and Richards accessible surface: validation of a high-resolution graphical tool for drug design.

Bohacek RS, McMartin C. Bohacek RS, et al. J Med Chem. 1992 May 15;35(10):1671-84. doi: 10.1021/jm00088a002. J Med Chem. 1992. PMID: 1588550

10

Characterization of the S3 subsite specificity of cathepsin B.

Taralp A, Kaplan H, Sytwu II, Vlattas I, Bohacek R, Knap AK, Hirama T, Huber CP, Hasnain S. Taralp A, et al. J Biol Chem. 1995 Jul 28;270(30):18036-43. doi: 10.1074/jbc.270.30.18036. J Biol Chem. 1995. PMID: 7629112 Free article.

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