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30-Day spexin treatment of mice with diet-induced obesity (DIO) and type 2 diabetes (T2DM) increases insulin sensitivity, improves liver functions and metabolic status.
Kolodziejski PA, Leciejewska N, Chmurzynska A, Sassek M, Szczepankiewicz A, Szczepankiewicz D, Malek E, Strowski MZ, Checinska-Maciejewska Z, Nowak KW, Pruszynska-Oszmalek E. Kolodziejski PA, et al. Among authors: strowski mz. Mol Cell Endocrinol. 2021 Oct 1;536:111420. doi: 10.1016/j.mce.2021.111420. Epub 2021 Aug 9. Mol Cell Endocrinol. 2021. PMID: 34384849 Free article.
Somatostatin receptor subtype-2-deficient mice with diet-induced obesity have hyperglycemia, nonfasting hyperglucagonemia, and decreased hepatic glycogen deposition.
Singh V, Grötzinger C, Nowak KW, Zacharias S, Göncz E, Pless G, Sauer IM, Eichhorn I, Pfeiffer-Guglielmi B, Hamprecht B, Wiedenmann B, Plöckinger U, Strowski MZ. Singh V, et al. Among authors: strowski mz. Endocrinology. 2007 Aug;148(8):3887-99. doi: 10.1210/en.2006-1659. Epub 2007 May 24. Endocrinology. 2007. PMID: 17525126
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