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Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution.
Allen TM, Altfeld M, Geer SC, Kalife ET, Moore C, O'sullivan KM, Desouza I, Feeney ME, Eldridge RL, Maier EL, Kaufmann DE, Lahaie MP, Reyor L, Tanzi G, Johnston MN, Brander C, Draenert R, Rockstroh JK, Jessen H, Rosenberg ES, Mallal SA, Walker BD. Allen TM, et al. Among authors: eldridge rl. J Virol. 2005 Nov;79(21):13239-49. doi: 10.1128/JVI.79.21.13239-13249.2005. J Virol. 2005. PMID: 16227247 Free PMC article.
Immune control of HIV-1 after early treatment of acute infection.
Rosenberg ES, Altfeld M, Poon SH, Phillips MN, Wilkes BM, Eldridge RL, Robbins GK, D'Aquila RT, Goulder PJ, Walker BD. Rosenberg ES, et al. Among authors: eldridge rl. Nature. 2000 Sep 28;407(6803):523-6. doi: 10.1038/35035103. Nature. 2000. PMID: 11029005 Clinical Trial.
Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection.
Altfeld M, Rosenberg ES, Shankarappa R, Mukherjee JS, Hecht FM, Eldridge RL, Addo MM, Poon SH, Phillips MN, Robbins GK, Sax PE, Boswell S, Kahn JO, Brander C, Goulder PJ, Levy JA, Mullins JI, Walker BD. Altfeld M, et al. Among authors: eldridge rl. J Exp Med. 2001 Jan 15;193(2):169-80. doi: 10.1084/jem.193.2.169. J Exp Med. 2001. PMID: 11148221 Free PMC article.
The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals.
Addo MM, Altfeld M, Rosenberg ES, Eldridge RL, Philips MN, Habeeb K, Khatri A, Brander C, Robbins GK, Mazzara GP, Goulder PJ, Walker BD; HIV Controller Study Collaboration. Addo MM, et al. Among authors: eldridge rl. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1781-6. doi: 10.1073/pnas.98.4.1781. Proc Natl Acad Sci U S A. 2001. PMID: 11172028 Free PMC article.
Vpr is preferentially targeted by CTL during HIV-1 infection.
Altfeld M, Addo MM, Eldridge RL, Yu XG, Thomas S, Khatri A, Strick D, Phillips MN, Cohen GB, Islam SA, Kalams SA, Brander C, Goulder PJ, Rosenberg ES, Walker BD; HIV Study Collaboration. Altfeld M, et al. Among authors: eldridge rl. J Immunol. 2001 Sep 1;167(5):2743-52. doi: 10.4049/jimmunol.167.5.2743. J Immunol. 2001. PMID: 11509618
Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.
Addo MM, Yu XG, Rathod A, Cohen D, Eldridge RL, Strick D, Johnston MN, Corcoran C, Wurcel AG, Fitzpatrick CA, Feeney ME, Rodriguez WR, Basgoz N, Draenert R, Stone DR, Brander C, Goulder PJ, Rosenberg ES, Altfeld M, Walker BD. Addo MM, et al. Among authors: eldridge rl. J Virol. 2003 Feb;77(3):2081-92. doi: 10.1128/jvi.77.3.2081-2092.2003. J Virol. 2003. PMID: 12525643 Free PMC article.
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