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Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer.
Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT, Chung DC, Sahani DV, Kalva SP, Kozin SV, Mino M, Cohen KS, Scadden DT, Hartford AC, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Chen HX, Shellito PC, Lauwers GY, Jain RK. Willett CG, et al. Among authors: di tomaso e. Nat Med. 2004 Feb;10(2):145-7. doi: 10.1038/nm988. Epub 2004 Jan 25. Nat Med. 2004. PMID: 14745444 Free PMC article. Clinical Trial.
Pathology: cancer cells compress intratumour vessels.
Padera TP, Stoll BR, Tooredman JB, Capen D, di Tomaso E, Jain RK. Padera TP, et al. Among authors: di tomaso e. Nature. 2004 Feb 19;427(6976):695. doi: 10.1038/427695a. Nature. 2004. PMID: 14973470
Angiogenesis in brain tumours.
Jain RK, di Tomaso E, Duda DG, Loeffler JS, Sorensen AG, Batchelor TT. Jain RK, et al. Among authors: di tomaso e. Nat Rev Neurosci. 2007 Aug;8(8):610-22. doi: 10.1038/nrn2175. Nat Rev Neurosci. 2007. PMID: 17643088 Review.
69 results