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Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide.
de Haan JB, Bladier C, Griffiths P, Kelner M, O'Shea RD, Cheung NS, Bronson RT, Silvestro MJ, Wild S, Zheng SS, Beart PM, Hertzog PJ, Kola I. de Haan JB, et al. Among authors: beart pm. J Biol Chem. 1998 Aug 28;273(35):22528-36. doi: 10.1074/jbc.273.35.22528. J Biol Chem. 1998. PMID: 9712879 Free article.
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