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Page 1
The role of melanocortins in body weight regulation: opportunities for the treatment of obesity.
MacNeil DJ, Howard AD, Guan X, Fong TM, Nargund RP, Bednarek MA, Goulet MT, Weinberg DH, Strack AM, Marsh DJ, Chen HY, Shen CP, Chen AS, Rosenblum CI, MacNeil T, Tota M, MacIntyre ED, Van der Ploeg LH. MacNeil DJ, et al. Among authors: macintyre ed. Eur J Pharmacol. 2002 Apr 12;440(2-3):141-57. doi: 10.1016/s0014-2999(02)01425-5. Eur J Pharmacol. 2002. PMID: 12007532 Corrected and republished. Review.
The role of melanocortins in body weight regulation: opportunities for the treatment of obesity.
MacNeil DJ, Howard AD, Guan X, Fong TM, Nargund RP, Bednarek MA, Goulet MT, Weinberg DH, Strack AM, Marsh DJ, Chen HY, Shen CP, Chen AS, Rosenblum CI, MacNeil T, Tota M, MacIntyre ED, Van der Ploeg LH. MacNeil DJ, et al. Among authors: macintyre ed. Eur J Pharmacol. 2002 Aug 16;450(1):93-109. doi: 10.1016/s0014-2999(02)01989-1. Eur J Pharmacol. 2002. PMID: 12176114 Review.
Synthesis and SAR of potent and orally bioavailable tert-butylpyrrolidine archetype derived melanocortin subtype-4 receptor modulators.
Guo L, Ye Z, Ujjainwalla F, Sings HL, Sebhat IK, Huber J, Weinberg DH, Tang R, MacNeil T, Tamvakopoulos C, Peng Q, MacIntyre E, van der Ploeg LH, Goulet MT, Wyvratt MJ, Nargund RP. Guo L, et al. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3242-7. doi: 10.1016/j.bmcl.2008.04.049. Epub 2008 Apr 25. Bioorg Med Chem Lett. 2008. PMID: 18479920
Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors.
Edmondson SD, Mastracchio A, He J, Chung CC, Forrest MJ, Hofsess S, MacIntyre E, Metzger J, O'Connor N, Patel K, Tong X, Tota MR, Van der Ploeg LH, Varnerin JP, Fisher MH, Wyvratt MJ, Weber AE, Parmee ER. Edmondson SD, et al. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3983-7. doi: 10.1016/j.bmcl.2003.08.056. Bioorg Med Chem Lett. 2003. PMID: 14592490
Identification of glucose-dependant insulin secretion targets in pancreatic beta cells by combining defined-mechanism compound library screening and siRNA gene silencing.
Wu W, Shang J, Feng Y, Thompson CM, Horwitz S, Thompson JR, MacIntyre ED, Thornberry NA, Chapman K, Zhou YP, Howard AD, Li J. Wu W, et al. Among authors: macintyre ed. J Biomol Screen. 2008 Feb;13(2):128-34. doi: 10.1177/1087057107313763. Epub 2008 Jan 23. J Biomol Screen. 2008. PMID: 18216393
L-750355, a human beta3-adrenoceptor agonist; in vitro pharmacology and profile of activity in vivo in the rhesus monkey.
Forrest MJ, Hom G, Bach T, Candelore MR, Cascieri MA, Strader C, Tota L, Fisher MH, Szumiloski J, Ok HO, Weber AE, Wyvratt M, Vicario P, Marko O, Deng L, Cioffe C, Hegarty-Friscino B, MacIntyre E. Forrest MJ, et al. Eur J Pharmacol. 2000 Oct 27;407(1-2):175-81. doi: 10.1016/s0014-2999(00)00724-x. Eur J Pharmacol. 2000. PMID: 11050305