Neale K - Search Results

1

Explaining variation in familial adenomatous polyposis: relationship between genotype and phenotype and evidence for modifier genes.

Crabtree MD, Tomlinson IP, Hodgson SV, Neale K, Phillips RK, Houlston RS. Crabtree MD, et al. Among authors: neale k. Gut. 2002 Sep;51(3):420-3. doi: 10.1136/gut.51.3.420. Gut. 2002. PMID: 12171967 Free PMC article.

2

Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients.

Crabtree M, Sieber OM, Lipton L, Hodgson SV, Lamlum H, Thomas HJ, Neale K, Phillips RK, Heinimann K, Tomlinson IP. Crabtree M, et al. Among authors: neale k. Oncogene. 2003 Jul 3;22(27):4257-65. doi: 10.1038/sj.onc.1206471. Oncogene. 2003. PMID: 12833148

3

Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations.

Segditsas S, Sieber OM, Rowan A, Setien F, Neale K, Phillips RK, Ward R, Esteller M, Tomlinson IP. Segditsas S, et al. Among authors: neale k. Exp Mol Pathol. 2008 Dec;85(3):201-6. doi: 10.1016/j.yexmp.2008.09.006. Epub 2008 Oct 11. Exp Mol Pathol. 2008. PMID: 18977219

4

Juvenile polyposis.

Desai DC, Neale KF, Talbot IC, Hodgson SV, Phillips RK. Desai DC, et al. Among authors: neale kf. Br J Surg. 1995 Jan;82(1):14-7. doi: 10.1002/bjs.1800820106. Br J Surg. 1995. PMID: 7881943 Review.

5

Evidence for genetic predisposition to desmoid tumours in familial adenomatous polyposis independent of the germline APC mutation.

Sturt NJ, Gallagher MC, Bassett P, Philp CR, Neale KF, Tomlinson IP, Silver AR, Phillips RK. Sturt NJ, et al. Among authors: neale kf. Gut. 2004 Dec;53(12):1832-6. doi: 10.1136/gut.2004.042705. Gut. 2004. PMID: 15542524 Free PMC article.

6

A modifying locus for familial adenomatous polyposis may be present on chromosome 1p35-p36.

Tomlinson IP, Neale K, Talbot IC, Spigelman AD, Williams CB, Phillips RK, Bodmer WF. Tomlinson IP, et al. Among authors: neale k. J Med Genet. 1996 Apr;33(4):268-73. doi: 10.1136/jmg.33.4.268. J Med Genet. 1996. PMID: 8730279 Free PMC article.

7

Variants at the secretory phospholipase A2 (PLA2G2A) locus: analysis of associations with familial adenomatous polyposis and sporadic colorectal tumours.

Tomlinson IP, Beck NE, Neale K, Bodmer WF. Tomlinson IP, et al. Among authors: neale k. Ann Hum Genet. 1996 Sep;60(5):369-76. doi: 10.1111/j.1469-1809.1996.tb00434.x. Ann Hum Genet. 1996. PMID: 8912789

8

Screening SMAD1, SMAD2, SMAD3, and SMAD5 for germline mutations in juvenile polyposis syndrome.

Bevan S, Woodford-Richens K, Rozen P, Eng C, Young J, Dunlop M, Neale K, Phillips R, Markie D, Rodriguez-Bigas M, Leggett B, Sheridan E, Hodgson S, Iwama T, Eccles D, Bodmer W, Houlston R, Tomlinson I. Bevan S, et al. Among authors: neale k. Gut. 1999 Sep;45(3):406-8. doi: 10.1136/gut.45.3.406. Gut. 1999. PMID: 10446110 Free PMC article.

9

The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis.

Lamlum H, Ilyas M, Rowan A, Clark S, Johnson V, Bell J, Frayling I, Efstathiou J, Pack K, Payne S, Roylance R, Gorman P, Sheer D, Neale K, Phillips R, Talbot I, Bodmer W, Tomlinson I. Lamlum H, et al. Among authors: neale k. Nat Med. 1999 Sep;5(9):1071-5. doi: 10.1038/12511. Nat Med. 1999. PMID: 10470088

10

Analysis of genetic and phenotypic heterogeneity in juvenile polyposis.

Woodford-Richens K, Bevan S, Churchman M, Dowling B, Jones D, Norbury CG, Hodgson SV, Desai D, Neale K, Phillips RK, Young J, Leggett B, Dunlop M, Rozen P, Eng C, Markie D, Rodriguez-Bigas MA, Sheridan E, Iwama T, Eccles D, Smith GT, Kim JC, Kim KM, Sampson JR, Evans G, Tejpar S, Bodmer WF, Tomlinson IP, Houlston RS. Woodford-Richens K, et al. Among authors: neale k. Gut. 2000 May;46(5):656-60. doi: 10.1136/gut.46.5.656. Gut. 2000. PMID: 10764709 Free PMC article.

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