Ryckmans T - Search Results

1

Dual NK(1) antagonists--serotonin reuptake inhibitors as potential antidepressants. Part 2: SAR and activity of benzyloxyphenethyl piperazine derivatives.

Ryckmans T, Berton O, Grimée R, Kogej T, Lamberty Y, Pasau P, Talaga P, Genicot C. Ryckmans T, et al. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3195-8. doi: 10.1016/s0960-894x(02)00563-2. Bioorg Med Chem Lett. 2002. PMID: 12372532

2

First dual NK(1) antagonists-serotonin reuptake inhibitors: synthesis and SAR of a new class of potential antidepressants.

Ryckmans T, Balançon L, Berton O, Genicot C, Lamberty Y, Lallemand B, Pasau P, Pirlot N, Quéré L, Talaga P. Ryckmans T, et al. Bioorg Med Chem Lett. 2002 Jan 21;12(2):261-4. doi: 10.1016/s0960-894x(01)00727-2. Bioorg Med Chem Lett. 2002. PMID: 11755367

3

Discovery of orally bioavailable NK1 receptor antagonists.

Genicot C, Christophe B, Collart P, Gillard M, Goossens L, Hénichart JP, Lassoie MA, Moureau F, Neuwels M, Nicolas JM, Pasau P, Quéré L, Ryckmans T, Stiernet F, Taverne T, Van Keulen BJ. Genicot C, et al. Among authors: ryckmans t. Bioorg Med Chem Lett. 2003 Feb 10;13(3):437-42. doi: 10.1016/s0960-894x(02)00956-3. Bioorg Med Chem Lett. 2003. PMID: 12565946

4

Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition.

Fish PV, Deur C, Gan X, Greene K, Hoople D, Mackenny M, Para KS, Reeves K, Ryckmans T, Stiff C, Stobie A, Wakenhut F, Whitlock GA. Fish PV, et al. Among authors: ryckmans t. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2562-6. doi: 10.1016/j.bmcl.2008.03.050. Epub 2008 Mar 20. Bioorg Med Chem Lett. 2008. PMID: 18387300

5

[4-(Phenoxy)pyridin-3-yl]methylamines: a new class of selective noradrenaline reuptake inhibitors.

Fish PV, Ryckmans T, Stobie A, Wakenhut F. Fish PV, et al. Among authors: ryckmans t. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1795-8. doi: 10.1016/j.bmcl.2008.02.036. Epub 2008 Feb 16. Bioorg Med Chem Lett. 2008. PMID: 18313294

6

N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: impact of small structural modifications on P-gp recognition and CNS penetration.

Wakenhut F, Allan GA, Fish PV, Fray MJ, Harrison AC, McCoy R, Phillips SC, Ryckmans T, Stobie A, Westbrook D, Westbrook SL, Whitlock GA. Wakenhut F, et al. Among authors: ryckmans t. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5078-81. doi: 10.1016/j.bmcl.2009.07.049. Epub 2009 Jul 31. Bioorg Med Chem Lett. 2009. PMID: 19647430

7

Design, synthesis and evaluation of N-[(3S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more polar template.

Fish PV, Wakenhut F, Ryckmans T, Stobie A. Fish PV, et al. Among authors: ryckmans t. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4579-83. doi: 10.1016/j.bmcl.2009.06.096. Epub 2009 Jul 2. Bioorg Med Chem Lett. 2009. PMID: 19616432

8

Derivatives of (3S)-N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modulation of H-bond acceptor capacity.

Fish PV, Barta NS, Gray DL, Ryckmans T, Stobie A, Wakenhut F, Whitlock GA. Fish PV, et al. Among authors: ryckmans t. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4355-9. doi: 10.1016/j.bmcl.2008.06.071. Epub 2008 Jun 25. Bioorg Med Chem Lett. 2008. PMID: 18621528

9

Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel.

Ryckmans T, Aubdool AA, Bodkin JV, Cox P, Brain SD, Dupont T, Fairman E, Hashizume Y, Ishii N, Kato T, Kitching L, Newman J, Omoto K, Rawson D, Strover J. Ryckmans T, et al. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4857-9. doi: 10.1016/j.bmcl.2011.06.035. Epub 2011 Jun 21. Bioorg Med Chem Lett. 2011. PMID: 21741838

10

Rapid assessment of a novel series of selective CB(2) agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis.

Ryckmans T, Edwards MP, Horne VA, Correia AM, Owen DR, Thompson LR, Tran I, Tutt MF, Young T. Ryckmans T, et al. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4406-9. doi: 10.1016/j.bmcl.2009.05.062. Epub 2009 May 21. Bioorg Med Chem Lett. 2009. PMID: 19500981

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