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The designer anti-angiogenic peptide anginex targets tumor endothelial cells and inhibits tumor growth in animal models.
FASEB J. 2002 Dec;16(14):1991-3. doi: 10.1096/fj.02-0509fje. Epub 2002 Oct 18.
FASEB J. 2002.
PMID: 12397082
Vascular targeting effect of combretastatin A-4 phosphate dominates the inherent angiogenesis inhibitory activity.
Ahmed B, Van Eijk LI, Bouma-Ter Steege JC, Van Der Schaft DW, Van Esch AM, Joosten-Achjanie SR, Lambin P, Landuyt W, Griffioen AW.
Ahmed B, et al. Among authors: van eijk li.
Int J Cancer. 2003 May 20;105(1):20-5. doi: 10.1002/ijc.11010.
Int J Cancer. 2003.
PMID: 12672025
Free article.
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Beta-sheet is the bioactive conformation of the anti-angiogenic anginex peptide.
Dings RP, Arroyo MM, Lockwood NA, van Eijk LI, Haseman JR, Griffioen AW, Mayo KH.
Dings RP, et al. Among authors: van eijk li.
Biochem J. 2003 Jul 1;373(Pt 1):281-8. doi: 10.1042/BJ20030295.
Biochem J. 2003.
PMID: 12708970
Free PMC article.
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Design of a partial peptide mimetic of anginex with antiangiogenic and anticancer activity.
Mayo KH, Dings RP, Flader C, Nesmelova I, Hargittai B, van der Schaft DW, van Eijk LI, Walek D, Haseman J, Hoye TR, Griffioen AW.
Mayo KH, et al. Among authors: van eijk li.
J Biol Chem. 2003 Nov 14;278(46):45746-52. doi: 10.1074/jbc.M308608200. Epub 2003 Aug 28.
J Biol Chem. 2003.
PMID: 12947097
Free article.
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Design of nonpeptidic topomimetics of antiangiogenic proteins with antitumor activities.
Dings RP, Chen X, Hellebrekers DM, van Eijk LI, Zhang Y, Hoye TR, Griffioen AW, Mayo KH.
Dings RP, et al. Among authors: van eijk li.
J Natl Cancer Inst. 2006 Jul 5;98(13):932-6. doi: 10.1093/jnci/djj247.
J Natl Cancer Inst. 2006.
PMID: 16818857
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Platelet factor 4 and interleukin-8 CXC chemokine heterodimer formation modulates function at the quaternary structural level.
Nesmelova IV, Sham Y, Dudek AZ, van Eijk LI, Wu G, Slungaard A, Mortari F, Griffioen AW, Mayo KH.
Nesmelova IV, et al. Among authors: van eijk li.
J Biol Chem. 2005 Feb 11;280(6):4948-58. doi: 10.1074/jbc.M405364200. Epub 2004 Nov 5.
J Biol Chem. 2005.
PMID: 15531763
Free article.
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