Liu EC - Search Results

1

Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist.

Murugesan N, Gu Z, Spergel S, Young M, Chen P, Mathur A, Leith L, Hermsmeier M, Liu EC, Zhang R, Bird E, Waldron T, Marino A, Koplowitz B, Humphreys WG, Chong S, Morrison RA, Webb ML, Moreland S, Trippodo N, Barrish JC. Murugesan N, et al. Among authors: liu ec. J Med Chem. 2003 Jan 2;46(1):125-37. doi: 10.1021/jm020289q. J Med Chem. 2003. PMID: 12502366

2

Biphenylsulfonamide endothelin receptor antagonists. Part 3: structure-activity relationship of 4'-heterocyclic biphenylsulfonamides.

Murugesan N, Gu Z, Stein PD, Spergel S, Bisaha S, Liu EC, Zhang R, Webb ML, Moreland S, Barrish JC. Murugesan N, et al. Among authors: liu ec. Bioorg Med Chem Lett. 2002 Feb 25;12(4):517-20. doi: 10.1016/s0960-894x(01)00791-0. Bioorg Med Chem Lett. 2002. PMID: 11844662

3

The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulf onamide.

Stein PD, Hunt JT, Floyd DM, Moreland S, Dickinson KE, Mitchell C, Liu EC, Webb ML, Murugesan N, Dickey J, et al. Stein PD, et al. Among authors: liu ec. J Med Chem. 1994 Feb 4;37(3):329-31. doi: 10.1021/jm00029a001. J Med Chem. 1994. PMID: 8308857 No abstract available.

4

Biphenylsulfonamide endothelin antagonists: structure-activity relationships of a series of mono- and disubstituted analogues and pharmacology of the orally active endothelin antagonist 2'-amino-N- (3,4-dimethyl-5-isoxazolyl)-4'-(2-methylpropyl)[1, 1'-biphenyl]-2-sulfonamide (BMS-187308).

Murugesan N, Gu Z, Stein PD, Bisaha S, Spergel S, Girotra R, Lee VG, Lloyd J, Misra RN, Schmidt J, Mathur A, Stratton L, Kelly YF, Bird E, Waldron T, Liu EC, Zhang R, Lee H, Serafino R, Abboa-Offei B, Mathers P, Giancarli M, Seymour AA, Webb ML, Hunt JT, et al. Murugesan N, et al. Among authors: liu ec. J Med Chem. 1998 Dec 17;41(26):5198-218. doi: 10.1021/jm970872k. J Med Chem. 1998. PMID: 9857090

5

Biphenylsulfonamide endothelin receptor antagonists. 2. Discovery of 4'-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ET(A) antagonists.

Murugesan N, Gu Z, Stein PD, Spergel S, Mathur A, Leith L, Liu EC, Zhang R, Bird E, Waldron T, Marino A, Morrison RA, Webb ML, Moreland S, Barrish JC. Murugesan N, et al. Among authors: liu ec. J Med Chem. 2000 Aug 10;43(16):3111-7. doi: 10.1021/jm000105c. J Med Chem. 2000. PMID: 10956219

6

BMS-182874 is a selective, nonpeptide endothelin ETA receptor antagonist.

Webb ML, Bird JE, Liu EC, Rose PM, Serafino R, Stein PD, Moreland S. Webb ML, et al. Among authors: liu ec. J Pharmacol Exp Ther. 1995 Mar;272(3):1124-34. J Pharmacol Exp Ther. 1995. PMID: 7891325

7

Cyanoguanidine-based lactam derivatives as a novel class of orally bioavailable factor Xa inhibitors.

Shi Y, Zhang J, Shi M, O'Connor SP, Bisaha SN, Li C, Sitkoff D, Pudzianowski AT, Chong S, Klei HE, Kish K, Yanchunas J Jr, Liu EC, Hartl KS, Seiler SM, Steinbacher TE, Schumacher WA, Atwal KS, Stein PD. Shi Y, et al. Among authors: liu ec. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4034-41. doi: 10.1016/j.bmcl.2009.06.014. Epub 2009 Jun 13. Bioorg Med Chem Lett. 2009. PMID: 19541481

8

Discovery and structure-activity relationships of sulfonamide ETA-selective antagonists.

Stein PD, Floyd DM, Bisaha S, Dickey J, Girotra RN, Gougoutas JZ, Kozlowski M, Lee VG, Liu EC, Malley MF, et al. Stein PD, et al. Among authors: liu ec. J Med Chem. 1995 Apr 14;38(8):1344-54. doi: 10.1021/jm00008a013. J Med Chem. 1995. PMID: 7731020

9

The receptor binding affinity of monocyclic [Ala3,Xaa11]endothelin-1 analogs correlates with inducible helix length.

Andersen NH, Harris SM, Lee VG, Liu EC, Moreland S, Hunt JT. Andersen NH, et al. Among authors: liu ec. Bioorg Med Chem. 1995 Feb;3(2):113-24. doi: 10.1016/0968-0896(95)00005-2. Bioorg Med Chem. 1995. PMID: 7796045

10

Comparison of a novel ETA receptor antagonist and phosphoramidon in renal ischemia.

Bird JE, Webb ML, Wasserman AJ, Liu EC, Giancarli MR, Durham SK. Bird JE, et al. Among authors: liu ec. Pharmacology. 1995 Jan;50(1):9-23. doi: 10.1159/000139262. Pharmacology. 1995. PMID: 7899482

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