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Page 1
An assessment of the mechanistic differences between two integrin alpha 4 beta 1 inhibitors, the monoclonal antibody TA-2 and the small molecule BIO5192, in rat experimental autoimmune encephalomyelitis.
Leone DR, Giza K, Gill A, Dolinski BM, Yang W, Perper S, Scott DM, Lee WC, Cornebise M, Wortham K, Nickerson-Nutter C, Chen LL, LePage D, Spell JC, Whalley ET, Petter RC, Adams SP, Lobb RR, Pepinsky RB. Leone DR, et al. Among authors: wortham k. J Pharmacol Exp Ther. 2003 Jun;305(3):1150-62. doi: 10.1124/jpet.102.047332. Epub 2003 Mar 6. J Pharmacol Exp Ther. 2003. PMID: 12626659
Design, synthesis, and analysis of a polyethelene glycol-modified (PEGylated) small molecule inhibitor of integrin {alpha}4{beta}1 with improved pharmaceutical properties.
Pepinsky RB, Lee WC, Cornebise M, Gill A, Wortham K, Chen LL, Leone DR, Giza K, Dolinski BM, Perper S, Nickerson-Nutter C, Lepage D, Chakraborty A, Whalley ET, Petter RC, Adams SP, Lobb RR, Scott DM. Pepinsky RB, et al. Among authors: wortham k. J Pharmacol Exp Ther. 2005 Feb;312(2):742-50. doi: 10.1124/jpet.104.075648. Epub 2004 Oct 14. J Pharmacol Exp Ther. 2005. PMID: 15485895
Targeting the lymphotoxin-beta receptor with agonist antibodies as a potential cancer therapy.
Lukashev M, LePage D, Wilson C, Bailly V, Garber E, Lukashin A, Ngam-ek A, Zeng W, Allaire N, Perrin S, Xu X, Szeliga K, Wortham K, Kelly R, Bottiglio C, Ding J, Griffith L, Heaney G, Silverio E, Yang W, Jarpe M, Fawell S, Reff M, Carmillo A, Miatkowski K, Amatucci J, Crowell T, Prentice H, Meier W, Violette SM, Mackay F, Yang D, Hoffman R, Browning JL. Lukashev M, et al. Among authors: wortham k. Cancer Res. 2006 Oct 1;66(19):9617-24. doi: 10.1158/0008-5472.CAN-06-0217. Cancer Res. 2006. PMID: 17018619
Development of an Fn14 agonistic antibody as an anti-tumor agent.
Michaelson JS, Amatucci A, Kelly R, Su L, Garber E, Day ES, Berquist L, Cho S, Li Y, Parr M, Wille L, Schneider P, Wortham K, Burkly LC, Hsu YM, Joseph IB. Michaelson JS, et al. Among authors: wortham k. MAbs. 2011 Jul-Aug;3(4):362-75. doi: 10.4161/mabs.3.4.16090. Epub 2011 Jul 1. MAbs. 2011. PMID: 21697654 Free PMC article.
Stable IgG-like bispecific antibodies directed toward the type I insulin-like growth factor receptor demonstrate enhanced ligand blockade and anti-tumor activity.
Dong J, Sereno A, Snyder WB, Miller BR, Tamraz S, Doern A, Favis M, Wu X, Tran H, Langley E, Joseph I, Boccia A, Kelly R, Wortham K, Wang Q, Berquist L, Huang F, Gao SX, Zhang Y, Lugovskoy A, Martin S, Gouvis H, Berkowitz S, Chiang G, Reff M, Glaser SM, Hariharan K, Demarest SJ. Dong J, et al. Among authors: wortham k. J Biol Chem. 2011 Feb 11;286(6):4703-17. doi: 10.1074/jbc.M110.184317. Epub 2010 Dec 1. J Biol Chem. 2011. PMID: 21123183 Free PMC article.
Knockdown of β-catenin with dicer-substrate siRNAs reduces liver tumor burden in vivo.
Dudek H, Wong DH, Arvan R, Shah A, Wortham K, Ying B, Diwanji R, Zhou W, Holmes B, Yang H, Cyr WA, Zhou Y, Shah A, Farkiwala R, Lee M, Li Y, Rettig GR, Collingwood MA, Basu SK, Behlke MA, Brown BD. Dudek H, et al. Among authors: wortham k. Mol Ther. 2014 Jan;22(1):92-101. doi: 10.1038/mt.2013.233. Epub 2013 Oct 3. Mol Ther. 2014. PMID: 24089139 Free PMC article.
Revision rates after primary hip and knee replacement in England between 2003 and 2006.
Sibanda N, Copley LP, Lewsey JD, Borroff M, Gregg P, MacGregor AJ, Pickford M, Porter M, Tucker K, van der Meulen JH; Steering Committee of the National Joint Registry (NJR) for England and Wales. Sibanda N, et al. PLoS Med. 2008 Sep 30;5(9):e179. doi: 10.1371/journal.pmed.0050179. Epub 2008 Sep 2. PLoS Med. 2008. PMID: 18767900 Free PMC article.
23 results