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The CHEK2 1100delC mutation identifies families with a hereditary breast and colorectal cancer phenotype.
Meijers-Heijboer H, Wijnen J, Vasen H, Wasielewski M, Wagner A, Hollestelle A, Elstrodt F, van den Bos R, de Snoo A, Fat GT, Brekelmans C, Jagmohan S, Franken P, Verkuijlen P, van den Ouweland A, Chapman P, Tops C, Möslein G, Burn J, Lynch H, Klijn J, Fodde R, Schutte M. Meijers-Heijboer H, et al. Among authors: wijnen j. Am J Hum Genet. 2003 May;72(5):1308-14. doi: 10.1086/375121. Epub 2003 Apr 10. Am J Hum Genet. 2003. PMID: 12690581 Free PMC article.
CHEK2 1100delC is a susceptibility allele for HNPCC-related colorectal cancer.
Wasielewski M, Vasen H, Wijnen J, Hooning M, Dooijes D, Tops C, Klijn JG, Meijers-Heijboer H, Schutte M. Wasielewski M, et al. Among authors: wijnen j. Clin Cancer Res. 2008 Aug 1;14(15):4989-94. doi: 10.1158/1078-0432.CCR-08-0389. Clin Cancer Res. 2008. PMID: 18676774 Free article.
A 10-Mb paracentric inversion of chromosome arm 2p inactivates MSH2 and is responsible for hereditary nonpolyposis colorectal cancer in a North-American kindred.
Wagner A, van der Klift H, Franken P, Wijnen J, Breukel C, Bezrookove V, Smits R, Kinarsky Y, Barrows A, Franklin B, Lynch J, Lynch H, Fodde R. Wagner A, et al. Among authors: wijnen j. Genes Chromosomes Cancer. 2002 Sep;35(1):49-57. doi: 10.1002/gcc.10094. Genes Chromosomes Cancer. 2002. PMID: 12203789
TGFBR1*6A may contribute to hereditary colorectal cancer.
Bian Y, Caldes T, Wijnen J, Franken P, Vasen H, Kaklamani V, Nafa K, Peterlongo P, Ellis N, Baron JA, Burn J, Moeslein G, Morrison PJ, Chen Y, Ahsan H, Watson P, Lynch HT, de la Chapelle A, Fodde R, Pasche B. Bian Y, et al. Among authors: wijnen j. J Clin Oncol. 2005 May 1;23(13):3074-8. doi: 10.1200/JCO.2005.00.281. J Clin Oncol. 2005. PMID: 15860866
Molecular characterization of the spectrum of genomic deletions in the mismatch repair genes MSH2, MLH1, MSH6, and PMS2 responsible for hereditary nonpolyposis colorectal cancer (HNPCC).
van der Klift H, Wijnen J, Wagner A, Verkuilen P, Tops C, Otway R, Kohonen-Corish M, Vasen H, Oliani C, Barana D, Moller P, Delozier-Blanchet C, Hutter P, Foulkes W, Lynch H, Burn J, Möslein G, Fodde R. van der Klift H, et al. Among authors: wijnen j. Genes Chromosomes Cancer. 2005 Oct;44(2):123-38. doi: 10.1002/gcc.20219. Genes Chromosomes Cancer. 2005. PMID: 15942939
CHEK2*1100delC homozygosity in the Netherlands--prevalence and risk of breast and lung cancer.
Huijts PE, Hollestelle A, Balliu B, Houwing-Duistermaat JJ, Meijers CM, Blom JC, Ozturk B, Krol-Warmerdam EM, Wijnen J, Berns EM, Martens JW, Seynaeve C, Kiemeney LA, van der Heijden HF, Tollenaar RA, Devilee P, van Asperen CJ. Huijts PE, et al. Among authors: wijnen j. Eur J Hum Genet. 2014 Jan;22(1):46-51. doi: 10.1038/ejhg.2013.85. Epub 2013 May 8. Eur J Hum Genet. 2014. PMID: 23652375 Free PMC article.
405 results