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Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines.
Marinozzi M, Serpi M, Amori L, Gavilan Diaz M, Costantino G, Meyer U, Flor PJ, Gasparini F, Heckendorn R, Kuhn R, Giorgi G, Hermit MB, Thomsen C, Pellicciari R. Marinozzi M, et al. Among authors: flor pj. Bioorg Med Chem. 2007 May 1;15(9):3161-70. doi: 10.1016/j.bmc.2007.02.040. Epub 2007 Feb 22. Bioorg Med Chem. 2007. PMID: 17350267
Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior.
Gee CE, Peterlik D, Neuhäuser C, Bouhelal R, Kaupmann K, Laue G, Uschold-Schmidt N, Feuerbach D, Zimmermann K, Ofner S, Cryan JF, van der Putten H, Fendt M, Vranesic I, Glatthar R, Flor PJ. Gee CE, et al. Among authors: flor pj. J Biol Chem. 2014 Apr 18;289(16):10975-10987. doi: 10.1074/jbc.M113.542654. Epub 2014 Mar 4. J Biol Chem. 2014. PMID: 24596089 Free PMC article.
66 results