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Substitution of a single residue in Stichodactyla helianthus peptide, ShK-Dap22, reveals a novel pharmacological profile.
Middleton RE, Sanchez M, Linde AR, Bugianesi RM, Dai G, Felix JP, Koprak SL, Staruch MJ, Bruguera M, Cox R, Ghosh A, Hwang J, Jones S, Kohler M, Slaughter RS, McManus OB, Kaczorowski GJ, Garcia ML. Middleton RE, et al. Among authors: cox r. Biochemistry. 2003 Nov 25;42(46):13698-707. doi: 10.1021/bi035209e. Biochemistry. 2003. PMID: 14622016
Fmo induction as a tool to screen for pro-longevity drugs.
Huang S, Cox RL, Tuckowski A, Beydoun S, Bhat A, Howington MB, Sarker M, Miller H, Ruwe E, Wang E, Li X, Gardea EA, DeNicola D, Peterson W, Carrier JM, Miller RA, Sutphin GL, Leiser SF. Huang S, et al. Among authors: cox rl. Geroscience. 2024 May 24. doi: 10.1007/s11357-024-01207-y. Online ahead of print. Geroscience. 2024. PMID: 38787463
Host defence peptide plectasin targets bacterial cell wall precursor lipid II by a calcium-sensitive supramolecular mechanism.
Jekhmane S, Derks MGN, Maity S, Slingerland CJ, Tehrani KHME, Medeiros-Silva J, Charitou V, Ammerlaan D, Fetz C, Consoli NA, Cochrane RVK, Matheson EJ, van der Weijde M, Elenbaas BOW, Lavore F, Cox R, Lorent JH, Baldus M, Künzler M, Lelli M, Cochrane SA, Martin NI, Roos WH, Breukink E, Weingarth M. Jekhmane S, et al. Among authors: cox r. Nat Microbiol. 2024 May 23. doi: 10.1038/s41564-024-01696-9. Online ahead of print. Nat Microbiol. 2024. PMID: 38783023
3,105 results