Koprak SL - Search Results

1

Substitution of a single residue in Stichodactyla helianthus peptide, ShK-Dap22, reveals a novel pharmacological profile.

Middleton RE, Sanchez M, Linde AR, Bugianesi RM, Dai G, Felix JP, Koprak SL, Staruch MJ, Bruguera M, Cox R, Ghosh A, Hwang J, Jones S, Kohler M, Slaughter RS, McManus OB, Kaczorowski GJ, Garcia ML. Middleton RE, et al. Among authors: koprak sl. Biochemistry. 2003 Nov 25;42(46):13698-707. doi: 10.1021/bi035209e. Biochemistry. 2003. PMID: 14622016

2

A specific inhibitor of the p38 mitogen activated protein kinase affects differentially the production of various cytokines by activated human T cells: dependence on CD28 signaling and preferential inhibition of IL-10 production.

Koprak S, Staruch MJ, Dumont FJ. Koprak S, et al. Cell Immunol. 1999 Mar 15;192(2):87-95. doi: 10.1006/cimm.1998.1448. Cell Immunol. 1999. PMID: 10087176

3

Hypothemycin inhibits the proliferative response and modulates the production of cytokines during T cell activation.

Camacho R, Staruch MJ, DaSilva C, Koprak S, Sewell T, Salituro G, Dumont FJ. Camacho R, et al. Immunopharmacology. 1999 Nov;44(3):255-65. doi: 10.1016/s0162-3109(99)00085-5. Immunopharmacology. 1999. PMID: 10598882

4

The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin.

Dumont FJ, Staruch MJ, Koprak SL, Siekierka JJ, Lin CS, Harrison R, Sewell T, Kindt VM, Beattie TR, Wyvratt M, et al. Dumont FJ, et al. Among authors: koprak sl. J Exp Med. 1992 Sep 1;176(3):751-60. doi: 10.1084/jem.176.3.751. J Exp Med. 1992. PMID: 1380976 Free PMC article.

5

Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?

Sigal NH, Dumont F, Durette P, Siekierka JJ, Peterson L, Rich DH, Dunlap BE, Staruch MJ, Melino MR, Koprak SL, et al. Sigal NH, et al. Among authors: koprak sl. J Exp Med. 1991 Mar 1;173(3):619-28. doi: 10.1084/jem.173.3.619. J Exp Med. 1991. PMID: 1997649 Free PMC article.

6

Potent immunosuppressive C32-O-arylethyl ether derivatives of ascomycin with reduced toxicity.

Armstrong HM, Wong F, Holmes MA, Sinclair PJ, Goulet MT, Dumont FJ, Staruch MJ, Koprak S, Peterson LB, Rosa R, Wilusz MB, Wiederrecht GJ, Cryan JG, Wyvratt MJ, Parsons WH. Armstrong HM, et al. Bioorg Med Chem Lett. 1999 Jul 19;9(14):2089-94. doi: 10.1016/s0960-894x(99)00336-4. Bioorg Med Chem Lett. 1999. PMID: 10450987

7

The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells.

Dumont FJ, Melino MR, Staruch MJ, Koprak SL, Fischer PA, Sigal NH. Dumont FJ, et al. Among authors: koprak sl. J Immunol. 1990 Feb 15;144(4):1418-24. J Immunol. 1990. PMID: 1689353

8

Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin.

Dumont FJ, Staruch MJ, Koprak SL, Melino MR, Sigal NH. Dumont FJ, et al. Among authors: koprak sl. J Immunol. 1990 Jan 1;144(1):251-8. J Immunol. 1990. PMID: 1688572

9

C32-O-imidazol-2-yl-methyl ether derivatives of the immunosuppressant ascomycin with improved therapeutic potential.

Goulet MT, McAlpine SR, Staruch MJ, Koprak S, Dumont FJ, Cryan JG, Wiederrecht GJ, Rosa R, Wilusz MB, Peterson LB, Wyvratt MJ, Parsons WH. Goulet MT, et al. Bioorg Med Chem Lett. 1998 Aug 18;8(16):2253-8. doi: 10.1016/s0960-894x(98)00397-7. Bioorg Med Chem Lett. 1998. PMID: 9873523

10

A tacrolimus-related immunosuppressant with reduced toxicity.

Dumont FJ, Koprak S, Staruch MJ, Talento A, Koo G, DaSilva C, Sinclair PJ, Wong F, Woods J, Barker J, Pivnichny J, Singer I, Sigal NH, Williamson AR, Parsons WH, Wyvratt M. Dumont FJ, et al. Transplantation. 1998 Jan 15;65(1):18-26. doi: 10.1097/00007890-199801150-00005. Transplantation. 1998. PMID: 9448138

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