Middleton RE - Search Results

1

Substitution of a single residue in Stichodactyla helianthus peptide, ShK-Dap22, reveals a novel pharmacological profile.

Middleton RE, Sanchez M, Linde AR, Bugianesi RM, Dai G, Felix JP, Koprak SL, Staruch MJ, Bruguera M, Cox R, Ghosh A, Hwang J, Jones S, Kohler M, Slaughter RS, McManus OB, Kaczorowski GJ, Garcia ML. Middleton RE, et al. Biochemistry. 2003 Nov 25;42(46):13698-707. doi: 10.1021/bi035209e. Biochemistry. 2003. PMID: 14622016

2

Two tarantula peptides inhibit activation of multiple sodium channels.

Middleton RE, Warren VA, Kraus RL, Hwang JC, Liu CJ, Dai G, Brochu RM, Kohler MG, Gao YD, Garsky VM, Bogusky MJ, Mehl JT, Cohen CJ, Smith MM. Middleton RE, et al. Biochemistry. 2002 Dec 17;41(50):14734-47. doi: 10.1021/bi026546a. Biochemistry. 2002. PMID: 12475222

3

A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model.

Priest BT, Garcia ML, Middleton RE, Brochu RM, Clark S, Dai G, Dick IE, Felix JP, Liu CJ, Reiseter BS, Schmalhofer WA, Shao PP, Tang YS, Chou MZ, Kohler MG, Smith MM, Warren VA, Williams BS, Cohen CJ, Martin WJ, Meinke PT, Parsons WH, Wafford KA, Kaczorowski GJ. Priest BT, et al. Among authors: middleton re. Biochemistry. 2004 Aug 3;43(30):9866-76. doi: 10.1021/bi0493259. Biochemistry. 2004. PMID: 15274641

4

Resiniferatoxin binds to the capsaicin receptor (TRPV1) near the extracellular side of the S4 transmembrane domain.

Chou MZ, Mtui T, Gao YD, Kohler M, Middleton RE. Chou MZ, et al. Among authors: middleton re. Biochemistry. 2004 Mar 9;43(9):2501-11. doi: 10.1021/bi035981h. Biochemistry. 2004. PMID: 14992587

5

A high-capacity membrane potential FRET-based assay for NaV1.8 channels.

Liu CJ, Priest BT, Bugianesi RM, Dulski PM, Felix JP, Dick IE, Brochu RM, Knaus HG, Middleton RE, Kaczorowski GJ, Slaughter RS, Garcia ML, Köhler MG. Liu CJ, et al. Among authors: middleton re. Assay Drug Dev Technol. 2006 Feb;4(1):37-48. doi: 10.1089/adt.2006.4.37. Assay Drug Dev Technol. 2006. PMID: 16506887

6

Delay of intracellular calcium transients using a calcium chelator: application to high-throughput screening of the capsaicin receptor ion channel and G-protein-coupled receptors.

Grant SK, Bansal A, Mitra A, Feighner SD, Dai G, Kaczorowski GJ, Middleton RE. Grant SK, et al. Among authors: middleton re. Anal Biochem. 2001 Jul 1;294(1):27-35. doi: 10.1006/abio.2001.5157. Anal Biochem. 2001. PMID: 11412002

7

Functional properties of the high-affinity TRPV1 (VR1) vanilloid receptor antagonist (4-hydroxy-5-iodo-3-methoxyphenylacetate ester) iodo-resiniferatoxin.

Seabrook GR, Sutton KG, Jarolimek W, Hollingworth GJ, Teague S, Webb J, Clark N, Boyce S, Kerby J, Ali Z, Chou M, Middleton R, Kaczorowski G, Jones AB. Seabrook GR, et al. J Pharmacol Exp Ther. 2002 Dec;303(3):1052-60. doi: 10.1124/jpet.102.040394. J Pharmacol Exp Ther. 2002. PMID: 12438527

8

Purification, reconstitution, and subunit composition of a voltage-gated chloride channel from Torpedo electroplax.

Middleton RE, Pheasant DJ, Miller C. Middleton RE, et al. Biochemistry. 1994 Nov 15;33(45):13189-98. doi: 10.1021/bi00249a005. Biochemistry. 1994. PMID: 7947726

9

Triazoloamides as potent γ-secretase modulators with reduced hERG liability.

Fischer C, Zultanski SL, Zhou H, Methot JL, Shah S, Nuthall H, Hughes BL, Smotrov N, Hill A, Szewczak AA, Moxham CM, Bays N, Middleton RE, Munoz B, Shearman MS. Fischer C, et al. Among authors: middleton re. Bioorg Med Chem Lett. 2012 May 1;22(9):3140-6. doi: 10.1016/j.bmcl.2012.03.054. Epub 2012 Mar 21. Bioorg Med Chem Lett. 2012. PMID: 22497762

10

The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors.

Hamblett CL, Methot JL, Mampreian DM, Sloman DL, Stanton MG, Kral AM, Fleming JC, Cruz JC, Chenard M, Ozerova N, Hitz AM, Wang H, Deshmukh SV, Nazef N, Harsch A, Hughes B, Dahlberg WK, Szewczak AA, Middleton RE, Mosley RT, Secrist JP, Miller TA. Hamblett CL, et al. Among authors: middleton re. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5300-9. doi: 10.1016/j.bmcl.2007.08.023. Epub 2007 Aug 16. Bioorg Med Chem Lett. 2007. PMID: 17761416

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