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72 results

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Page 1
A new class of glycogen phosphorylase inhibitors.
Lu Z, Bohn J, Bergeron R, Deng Q, Ellsworth KP, Geissler WM, Harris G, McCann PE, McKeever B, Myers RW, Saperstein R, Willoughby CA, Yao J, Chapman K. Lu Z, et al. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4125-8. doi: 10.1016/j.bmcl.2003.08.046. Bioorg Med Chem Lett. 2003. PMID: 14592521
Modeling aided design of potent glycogen phosphorylase inhibitors.
Deng Q, Lu Z, Bohn J, Ellsworth KP, Myers RW, Geissler WM, Harris G, Willoughby CA, Chapman K, McKeever B, Mosley R. Deng Q, et al. J Mol Graph Model. 2005 Apr;23(5):457-64. doi: 10.1016/j.jmgm.2005.01.001. J Mol Graph Model. 2005. PMID: 15781188
Combinatorial synthesis of 3-(amidoalkyl) and 3-(aminoalkyl)-2-arylindole derivatives: discovery of potent ligands for a variety of G-protein coupled receptors.
Willoughby CA, Hutchins SM, Rosauer KG, Dhar MJ, Chapman KT, Chicchi GG, Sadowski S, Weinberg DH, Patel S, Malkowitz L, Di Salvo J, Pacholok SG, Cheng K. Willoughby CA, et al. Among authors: chapman kt. Bioorg Med Chem Lett. 2002 Jan 7;12(1):93-6. doi: 10.1016/s0960-894x(01)00665-5. Bioorg Med Chem Lett. 2002. PMID: 11738581
Combinatorial synthesis of CCR5 antagonists.
Willoughby CA, Berk SC, Rosauer KG, Degrado S, Chapman KT, Gould SL, Springer MS, Malkowitz L, Schleif WA, Hazuda D, Miller M, Kessler J, Danzeisen R, Holmes K, Lineberger J, Carella A, Carver G, Emini EA. Willoughby CA, et al. Among authors: chapman kt. Bioorg Med Chem Lett. 2001 Dec 17;11(24):3137-41. doi: 10.1016/s0960-894x(01)00652-7. Bioorg Med Chem Lett. 2001. PMID: 11720860
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists: modifications of the arylpropylpiperidine side chains.
Lynch CL, Willoughby CA, Hale JJ, Holson EJ, Budhu RJ, Gentry AL, Rosauer KG, Caldwell CG, Chen P, Mills SG, MacCoss M, Berk S, Chen L, Chapman KT, Malkowitz L, Springer MS, Gould SL, DeMartino JA, Siciliano SJ, Cascieri MA, Carella A, Carver G, Holmes K, Schleif WA, Danzeisen R, Hazuda D, Kessler J, Lineberger J, Miller M, Emini EA. Lynch CL, et al. Among authors: chapman kt. Bioorg Med Chem Lett. 2003 Jan 6;13(1):119-23. doi: 10.1016/s0960-894x(02)00829-6. Bioorg Med Chem Lett. 2003. PMID: 12467630
1,3,4 Trisubstituted pyrrolidine CCR5 receptor antagonists bearing 4-aminoheterocycle substituted piperidine side chains.
Willoughby CA, Rosauer KG, Hale JJ, Budhu RJ, Mills SG, Chapman KT, MacCoss M, Malkowitz L, Springer MS, Gould SL, DeMartino JA, Siciliano SJ, Cascieri MA, Carella A, Carver G, Holmes K, Schleif WA, Danzeisen R, Hazuda D, Kessler J, Lineberger J, Miller M, Emini EA. Willoughby CA, et al. Among authors: chapman kt. Bioorg Med Chem Lett. 2003 Feb 10;13(3):427-31. doi: 10.1016/s0960-894x(02)00988-5. Bioorg Med Chem Lett. 2003. PMID: 12565944
Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities.
Tang H, Yan Y, Feng Z, de Jesus RK, Yang L, Levorse DA, Owens KA, Akiyama TE, Bergeron R, Castriota GA, Doebber TW, Ellsworth KP, Lassman ME, Li C, Wu MS, Zhang BB, Chapman KT, Mills SG, Berger JP, Pasternak A. Tang H, et al. Among authors: chapman kt. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6088-92. doi: 10.1016/j.bmcl.2010.08.047. Epub 2010 Aug 20. Bioorg Med Chem Lett. 2010. PMID: 20832306
72 results