Demarest KT - Search Results

1

Benzoxazinones as PPARgamma agonists. 2. SAR of the amide substituent and in vivo results in a type 2 diabetes model.

Rybczynski PJ, Zeck RE, Dudash J Jr, Combs DW, Burris TP, Yang M, Osborne MC, Chen X, Demarest KT. Rybczynski PJ, et al. Among authors: demarest kt. J Med Chem. 2004 Jan 1;47(1):196-209. doi: 10.1021/jm0301888. J Med Chem. 2004. PMID: 14695833

2

Benzoxazinones as PPARgamma agonists. part 1: SAR of three aromatic regions.

Rybczynski PJ, Zeck RE, Combs DW, Turchi I, Burris TP, Xu JZ, Yang M, Demarest KT. Rybczynski PJ, et al. Among authors: demarest kt. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2359-62. doi: 10.1016/s0960-894x(03)00401-3. Bioorg Med Chem Lett. 2003. PMID: 12824034

3

2,5-disubstituted 3,4-dihydro-2H-benzo[b][1,4]thiazepines as potent and selective V2 arginine vasopressin receptor antagonists.

Urbanski MJ, Chen RH, Demarest KT, Gunnet J, Look R, Ericson E, Murray WV, Rybczynski PJ, Zhang X. Urbanski MJ, et al. Among authors: demarest kt. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4031-4. doi: 10.1016/j.bmcl.2003.08.051. Bioorg Med Chem Lett. 2003. PMID: 14592501

4

Glycosylated dihydrochalcones as potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitors.

Dudash J Jr, Zhang X, Zeck RE, Johnson SG, Cox GG, Conway BR, Rybczynski PJ, Demarest KT. Dudash J Jr, et al. Among authors: demarest kt. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5121-5. doi: 10.1016/j.bmcl.2004.07.082. Bioorg Med Chem Lett. 2004. PMID: 15380212

5

Synthesis and evaluation of 3-anilino-quinoxalinones as glycogen phosphorylase inhibitors.

Dudash J Jr, Zhang Y, Moore JB, Look R, Liang Y, Beavers MP, Conway BR, Rybczynski PJ, Demarest KT. Dudash J Jr, et al. Among authors: demarest kt. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4790-3. doi: 10.1016/j.bmcl.2005.07.021. Bioorg Med Chem Lett. 2005. PMID: 16143521

6

Heteroaryl-O-glucosides as novel sodium glucose co-transporter 2 inhibitors. Part 1.

Zhang X, Urbanski M, Patel M, Zeck RE, Cox GG, Bian H, Conway BR, Pat Beavers M, Rybczynski PJ, Demarest KT. Zhang X, et al. Among authors: demarest kt. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5202-6. doi: 10.1016/j.bmcl.2005.08.067. Epub 2005 Sep 28. Bioorg Med Chem Lett. 2005. PMID: 16198559

7

Indole-glucosides as novel sodium glucose co-transporter 2 (SGLT2) inhibitors. Part 2.

Zhang X, Urbanski M, Patel M, Cox GG, Zeck RE, Bian H, Conway BR, Beavers MP, Rybczynski PJ, Demarest KT. Zhang X, et al. Among authors: demarest kt. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1696-701. doi: 10.1016/j.bmcl.2005.12.006. Epub 2005 Dec 27. Bioorg Med Chem Lett. 2006. PMID: 16380256

8

Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARalpha agonists.

Matthews JM, Chen X, Cryan E, Hlasta DJ, Rybczynski PJ, Strauss K, Tang Y, Xu JZ, Yang M, Zhou L, Demarest KT. Matthews JM, et al. Among authors: demarest kt. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6773-8. doi: 10.1016/j.bmcl.2007.10.041. Epub 2007 Oct 17. Bioorg Med Chem Lett. 2007. PMID: 18029176

9

Hepatic biotransformation of the new calcium-mimetic agent, RWJ-68025, in the rat and in man--API-MS/MS identification of metabolites.

Wu WN, McKown LA, Rybczynski PJ, Demarest K. Wu WN, et al. J Pharm Pharmacol. 2003 May;55(5):631-7. doi: 10.1211/002235703765344531. J Pharm Pharmacol. 2003. PMID: 12831505

10

In vivo characterization of a dual adenosine A2A/A1 receptor antagonist in animal models of Parkinson's disease.

Shook BC, Rassnick S, Osborne MC, Davis S, Westover L, Boulet J, Hall D, Rupert KC, Heintzelman GR, Hansen K, Chakravarty D, Bullington JL, Russell R, Branum S, Wells KM, Damon S, Youells S, Li X, Beauchamp DA, Palmer D, Reyes M, Demarest K, Tang Y, Rhodes K, Jackson PF. Shook BC, et al. J Med Chem. 2010 Nov 25;53(22):8104-15. doi: 10.1021/jm100971t. Epub 2010 Oct 25. J Med Chem. 2010. PMID: 20973483

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