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Benzoxazinones as PPARgamma agonists. 2. SAR of the amide substituent and in vivo results in a type 2 diabetes model.
J Med Chem. 2004 Jan 1;47(1):196-209. doi: 10.1021/jm0301888.
J Med Chem. 2004.
PMID: 14695833
Benzoxazinones as PPARgamma agonists. part 1: SAR of three aromatic regions.
Rybczynski PJ, Zeck RE, Combs DW, Turchi I, Burris TP, Xu JZ, Yang M, Demarest KT.
Rybczynski PJ, et al. Among authors: zeck re.
Bioorg Med Chem Lett. 2003 Jul 21;13(14):2359-62. doi: 10.1016/s0960-894x(03)00401-3.
Bioorg Med Chem Lett. 2003.
PMID: 12824034
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Glycosylated dihydrochalcones as potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitors.
Dudash J Jr, Zhang X, Zeck RE, Johnson SG, Cox GG, Conway BR, Rybczynski PJ, Demarest KT.
Dudash J Jr, et al. Among authors: zeck re.
Bioorg Med Chem Lett. 2004 Oct 18;14(20):5121-5. doi: 10.1016/j.bmcl.2004.07.082.
Bioorg Med Chem Lett. 2004.
PMID: 15380212
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Heteroaryl-O-glucosides as novel sodium glucose co-transporter 2 inhibitors. Part 1.
Zhang X, Urbanski M, Patel M, Zeck RE, Cox GG, Bian H, Conway BR, Pat Beavers M, Rybczynski PJ, Demarest KT.
Zhang X, et al. Among authors: zeck re.
Bioorg Med Chem Lett. 2005 Dec 1;15(23):5202-6. doi: 10.1016/j.bmcl.2005.08.067. Epub 2005 Sep 28.
Bioorg Med Chem Lett. 2005.
PMID: 16198559
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Indole-glucosides as novel sodium glucose co-transporter 2 (SGLT2) inhibitors. Part 2.
Zhang X, Urbanski M, Patel M, Cox GG, Zeck RE, Bian H, Conway BR, Beavers MP, Rybczynski PJ, Demarest KT.
Zhang X, et al. Among authors: zeck re.
Bioorg Med Chem Lett. 2006 Mar 15;16(6):1696-701. doi: 10.1016/j.bmcl.2005.12.006. Epub 2005 Dec 27.
Bioorg Med Chem Lett. 2006.
PMID: 16380256
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Pharmacological profile of a novel, non-TZD PPARgamma agonist.
Chen X, Osborne MC, Rybczynski PJ, Zeck R, Yang M, Xu J, Zhou L, Cryan E, Tang Y, Demarest KT.
Chen X, et al.
Diabetes Obes Metab. 2005 Sep;7(5):536-46. doi: 10.1111/j.1463-1326.2004.00425.x.
Diabetes Obes Metab. 2005.
PMID: 16050946
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