Grimshaw R - Search Results

1

A cancer research (UK) randomized phase II study of idoxifene in patients with locally advanced/metastatic breast cancer resistant to tamoxifen.

Johnston SR, Gumbrell LA, Evans TR, Coleman RE, Smith IE, Twelves CJ, Soukop M, Rea DW, Earl HM, Howell A, Jones A, Canney P, Powles TJ, Haynes BP, Nutley B, Grimshaw R, Jarman M, Halbert GW, Brampton M, Haviland J, Dowsett M, Coombes RC; Cancer Research UK Phase I/II Committee. Johnston SR, et al. Among authors: grimshaw r. Cancer Chemother Pharmacol. 2004 Apr;53(4):341-8. doi: 10.1007/s00280-003-0733-6. Epub 2004 Jan 13. Cancer Chemother Pharmacol. 2004. PMID: 14722733 Clinical Trial.

2

Idoxifene antagonizes estradiol-dependent MCF-7 breast cancer xenograft growth through sustained induction of apoptosis.

Johnston SR, Boeddinghaus IM, Riddler S, Haynes BP, Hardcastle IR, Rowlands M, Grimshaw R, Jarman M, Dowsett M. Johnston SR, et al. Among authors: grimshaw r. Cancer Res. 1999 Aug 1;59(15):3646-51. Cancer Res. 1999. PMID: 10446976

3

Oestrogen formation in breast: clinical and biological importance.

Dowsett M, Detre S, Rowlands M, Grimshaw R. Dowsett M, et al. Among authors: grimshaw r. J Endocrinol. 1996 Sep;150 Suppl:S59-63. J Endocrinol. 1996. PMID: 8943788

4

Homologs of idoxifene: variation of estrogen receptor binding and calmodulin antagonism with chain length.

Hardcastle IR, Rowlands MG, Grimshaw RM, Houghton J, Jarman M. Hardcastle IR, et al. Among authors: grimshaw rm. J Med Chem. 1996 Feb 16;39(4):999-1004. doi: 10.1021/jm9505472. J Med Chem. 1996. PMID: 8632423

5

Evidence that tamoxifen binds to calmodulin in a conformation different to that when binding to estrogen receptors, through structure-activity study on ring-fused analogues.

McCague R, Rowlands MG, Grimshaw R, Jarman M. McCague R, et al. Among authors: grimshaw r. Biochem Pharmacol. 1994 Oct 7;48(7):1355-61. doi: 10.1016/0006-2952(94)90557-6. Biochem Pharmacol. 1994. PMID: 7945433

6

The control and biological importance of intratumoural aromatase in breast cancer.

Dowsett M, Lee K, Macaulay VM, Detre S, Rowlands M, Grimshaw R. Dowsett M, et al. Among authors: grimshaw r. J Steroid Biochem Mol Biol. 1996 Jan;56(1-6 Spec No):145-50. doi: 10.1016/0960-0760(95)00231-6. J Steroid Biochem Mol Biol. 1996. PMID: 8603035 Review.

7

Inhibition of protein prenylation by metabolites of limonene.

Hardcastle IR, Rowlands MG, Barber AM, Grimshaw RM, Mohan MK, Nutley BP, Jarman M. Hardcastle IR, et al. Among authors: grimshaw rm. Biochem Pharmacol. 1999 Apr 1;57(7):801-9. doi: 10.1016/s0006-2952(98)00349-9. Biochem Pharmacol. 1999. PMID: 10075086

8

Antagonism of estrogen receptor and calmodulin association by antiestrogens is not dependent on an interaction with calmodulin.

Rowlands MG, Grimshaw R, Jarman M, Bouhoute A, Leclercq G. Rowlands MG, et al. Among authors: grimshaw r. Biochem Pharmacol. 1997 Jan 24;53(2):241-4. doi: 10.1016/s0006-2952(96)00603-x. Biochem Pharmacol. 1997. PMID: 9037257

9

A phase I study of SR-4554 via intravenous administration for noninvasive investigation of tumor hypoxia by magnetic resonance spectroscopy in patients with malignancy.

Seddon BM, Payne GS, Simmons L, Ruddle R, Grimshaw R, Tan S, Turner A, Raynaud F, Halbert G, Leach MO, Judson I, Workman P. Seddon BM, et al. Among authors: grimshaw r. Clin Cancer Res. 2003 Nov 1;9(14):5101-12. Clin Cancer Res. 2003. PMID: 14613987 Review.

10

The deuterium isotope effect for the alpha-hydroxylation of tamoxifen by rat liver microsomes accounts for the reduced genotoxicity of [D5-ethyl]tamoxifen.

Jarman M, Poon GK, Rowlands MG, Grimshaw RM, Horton MN, Potter GA, McCague R. Jarman M, et al. Among authors: grimshaw rm. Carcinogenesis. 1995 Apr;16(4):683-8. doi: 10.1093/carcin/16.4.683. Carcinogenesis. 1995. PMID: 7728943

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