Brady SF - Search Results

1

Rational design and synthesis of selective BACE-1 inhibitors.

Brady SF, Singh S, Crouthamel MC, Holloway MK, Coburn CA, Garsky VM, Bogusky M, Pennington MW, Vacca JP, Hazuda D, Lai MT. Brady SF, et al. Bioorg Med Chem Lett. 2004 Feb 9;14(3):601-4. doi: 10.1016/j.bmcl.2003.11.061. Bioorg Med Chem Lett. 2004. PMID: 14741251

2

Design of novel, potent, noncovalent inhibitors of thrombin with nonbasic P-1 substructures: rapid structure-activity studies by solid-phase synthesis.

Lumma WC Jr, Witherup KM, Tucker TJ, Brady SF, Sisko JT, Naylor-Olsen AM, Lewis SD, Lucas BJ, Vacca JP. Lumma WC Jr, et al. Among authors: brady sf. J Med Chem. 1998 Mar 26;41(7):1011-3. doi: 10.1021/jm9706933. J Med Chem. 1998. PMID: 9544200

3

Design and synthesis of a pro-drug of vinblastine targeted at treatment of prostate cancer with enhanced efficacy and reduced systemic toxicity.

Brady SF, Pawluczyk JM, Lumma PK, Feng DM, Wai JM, Jones R, DeFeo-Jones D, Wong BK, Miller-Stein C, Lin JH, Oliff A, Freidinger RM, Garsky VM. Brady SF, et al. J Med Chem. 2002 Oct 10;45(21):4706-15. doi: 10.1021/jm020139f. J Med Chem. 2002. PMID: 12361397

4

Amide and alpha-keto carbonyl inhibitors of thrombin based on arginine and lysine: synthesis, stability and biological characterization.

Brady SF, Sisko JT, Stauffer KJ, Colton CD, Qiu H, Lewis SD, Ng AS, Shafer JA, Bogusky MJ, Veber DF, et al. Brady SF, et al. Bioorg Med Chem. 1995 Aug;3(8):1063-78. doi: 10.1016/0968-0896(95)00105-p. Bioorg Med Chem. 1995. PMID: 7582980

5

Discovery and development of the novel potent orally active thrombin inhibitor N-(9-hydroxy-9-fluorenecarboxy)prolyl trans-4-aminocyclohexylmethyl amide (L-372,460): coapplication of structure-based design and rapid multiple analogue synthesis on solid support.

Brady SF, Stauffer KJ, Lumma WC, Smith GM, Ramjit HG, Lewis SD, Lucas BJ, Gardell SJ, Lyle EA, Appleby SD, Cook JJ, Holahan MA, Stranieri MT, Lynch JJ Jr, Lin JH, Chen IW, Vastag K, Naylor-Olsen AM, Vacca JP. Brady SF, et al. J Med Chem. 1998 Jan 29;41(3):401-6. doi: 10.1021/jm9705014. J Med Chem. 1998. PMID: 9464370

6

Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 position.

Tucker TJ, Brady SF, Lumma WC, Lewis SD, Gardell SJ, Naylor-Olsen AM, Yan Y, Sisko JT, Stauffer KJ, Lucas BJ, Lynch JJ, Cook JJ, Stranieri MT, Holahan MA, Lyle EA, Baskin EP, Chen IW, Dancheck KB, Krueger JA, Cooper CM, Vacca JP. Tucker TJ, et al. Among authors: brady sf. J Med Chem. 1998 Aug 13;41(17):3210-9. doi: 10.1021/jm9801713. J Med Chem. 1998. PMID: 9703466

7

The solution conformation of Ac-Pen-Arg-Gly-Asp-Cys-OH, a potent fibrinogen receptor antagonist.

Bogusky MJ, Naylor AM, Mertzman ME, Pitzenberger SM, Nutt RF, Brady SF, Colton CD, Veber DF. Bogusky MJ, et al. Among authors: brady sf. Biopolymers. 1993 Aug;33(8):1287-97. doi: 10.1002/bip.360330813. Biopolymers. 1993. PMID: 8364159

8

HIV-1 protease specificity of peptide cleavage is sufficient for processing of gag and pol polyproteins.

Darke PL, Nutt RF, Brady SF, Garsky VM, Ciccarone TM, Leu CT, Lumma PK, Freidinger RM, Veber DF, Sigal IS. Darke PL, et al. Among authors: brady sf. Biochem Biophys Res Commun. 1988 Oct 14;156(1):297-303. doi: 10.1016/s0006-291x(88)80839-8. Biochem Biophys Res Commun. 1988. PMID: 3052448

9

Synthesis and solution conformation of c(D-Trp-D-Cys(SO3-Na+)-Pro-D-Val-Leu), a potent endothelin-A receptor antagonist.

Bogusky MJ, Brady SF, Sisko JT, Nutt RF, Smith GM. Bogusky MJ, et al. Among authors: brady sf. Int J Pept Protein Res. 1993 Aug;42(2):194-203. doi: 10.1111/j.1399-3011.1993.tb00496.x. Int J Pept Protein Res. 1993. PMID: 8407113

10

NMR and molecular modeling characterization of RGD containing peptides.

Bogusky MJ, Naylor AM, Pitzenberger SM, Nutt RF, Brady SF, Colton CD, Sisko JT, Anderson PS, Veber DF. Bogusky MJ, et al. Among authors: brady sf. Int J Pept Protein Res. 1992 Jan;39(1):63-76. doi: 10.1111/j.1399-3011.1992.tb01557.x. Int J Pept Protein Res. 1992. PMID: 1634331

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

146 results

Search Page