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Kostmann syndrome: severe congenital neutropenia associated with defective expression of Bcl-2, constitutive mitochondrial release of cytochrome c, and excessive apoptosis of myeloid progenitor cells.
Carlsson G, Aprikyan AA, Tehranchi R, Dale DC, Porwit A, Hellström-Lindberg E, Palmblad J, Henter JI, Fadeel B. Carlsson G, et al. Blood. 2004 May 1;103(9):3355-61. doi: 10.1182/blood-2003-04-1011. Epub 2004 Feb 5. Blood. 2004. PMID: 14764541 Free article.
The WHO classification of MDS does make a difference.
Howe RB, Porwit-MacDonald A, Wanat R, Tehranchi R, Hellström-Lindberg E. Howe RB, et al. Blood. 2004 May 1;103(9):3265-70. doi: 10.1182/blood-2003-06-2124. Epub 2003 Dec 18. Blood. 2004. PMID: 14684416 Free article.
Negative effect of DNA hypermethylation on the outcome of intensive chemotherapy in older patients with high-risk myelodysplastic syndromes and acute myeloid leukemia following myelodysplastic syndrome.
Grövdal M, Khan R, Aggerholm A, Antunovic P, Astermark J, Bernell P, Engström LM, Kjeldsen L, Linder O, Nilsson L, Olsson A, Wallvik J, Tangen JM, Oberg G, Jacobsen SE, Hokland P, Porwit A, Hellström-Lindberg E. Grövdal M, et al. Clin Cancer Res. 2007 Dec 1;13(23):7107-12. doi: 10.1158/1078-0432.CCR-07-1193. Clin Cancer Res. 2007. PMID: 18056190 Clinical Trial.
Hypomethylation and apoptosis in 5-azacytidine-treated myeloid cells.
Khan R, Schmidt-Mende J, Karimi M, Gogvadze V, Hassan M, Ekström TJ, Zhivotovsky B, Hellström-Lindberg E. Khan R, et al. Exp Hematol. 2008 Feb;36(2):149-57. doi: 10.1016/j.exphem.2007.10.002. Exp Hematol. 2008. PMID: 18206726 Free article.
279 results