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All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia.
Shen ZX, Shi ZZ, Fang J, Gu BW, Li JM, Zhu YM, Shi JY, Zheng PZ, Yan H, Liu YF, Chen Y, Shen Y, Wu W, Tang W, Waxman S, De Thé H, Wang ZY, Chen SJ, Chen Z. Shen ZX, et al. Among authors: waxman s. Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5328-35. doi: 10.1073/pnas.0400053101. Epub 2004 Mar 24. Proc Natl Acad Sci U S A. 2004. PMID: 15044693 Free PMC article. Clinical Trial.
Variant-type PML-RAR(alpha) fusion transcript in acute promyelocytic leukemia: use of a cryptic coding sequence from intron 2 of the RAR(alpha) gene and identification of a new clinical subtype resistant to retinoic acid therapy.
Gu BW, Xiong H, Zhou Y, Chen B, Wang L, Dong S, Yu ZY, Lu LF, Zhong M, Yin HF, Zhu GF, Huang W, Ren SX, Gallagher RE, Waxman S, Chen GQ, Wang ZG, Chen Z, Fu G, Chen SJ. Gu BW, et al. Among authors: waxman s. Proc Natl Acad Sci U S A. 2002 May 28;99(11):7640-5. doi: 10.1073/pnas.112194799. Proc Natl Acad Sci U S A. 2002. PMID: 12032336 Free PMC article.
Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia.
Zheng PZ, Wang KK, Zhang QY, Huang QH, Du YZ, Zhang QH, Xiao DK, Shen SH, Imbeaud S, Eveno E, Zhao CJ, Chen YL, Fan HY, Waxman S, Auffray C, Jin G, Chen SJ, Chen Z, Zhang J. Zheng PZ, et al. Among authors: waxman s. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8. doi: 10.1073/pnas.0502825102. Epub 2005 May 13. Proc Natl Acad Sci U S A. 2005. PMID: 15894607 Free PMC article.
Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia.
Hu J, Liu YF, Wu CF, Xu F, Shen ZX, Zhu YM, Li JM, Tang W, Zhao WL, Wu W, Sun HP, Chen QS, Chen B, Zhou GB, Zelent A, Waxman S, Wang ZY, Chen SJ, Chen Z. Hu J, et al. Among authors: waxman s. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3342-7. doi: 10.1073/pnas.0813280106. Epub 2009 Feb 18. Proc Natl Acad Sci U S A. 2009. PMID: 19225113 Free PMC article.
Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion protein.
Dong S, Zhu J, Reid A, Strutt P, Guidez F, Zhong HJ, Wang ZY, Licht J, Waxman S, Chomienne C, Chen Z, Zelent A, Chen SJ. Dong S, et al. Among authors: waxman s. Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3624-9. doi: 10.1073/pnas.93.8.3624. Proc Natl Acad Sci U S A. 1996. PMID: 8622986 Free PMC article.
Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells.
Chen GQ, Shi XG, Tang W, Xiong SM, Zhu J, Cai X, Han ZG, Ni JH, Shi GY, Jia PM, Liu MM, He KL, Niu C, Ma J, Zhang P, Zhang TD, Paul P, Naoe T, Kitamura K, Miller W, Waxman S, Wang ZY, de The H, Chen SJ, Chen Z. Chen GQ, et al. Among authors: waxman s. Blood. 1997 May 1;89(9):3345-53. Blood. 1997. PMID: 9129041 Free article.
Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genes.
Yu M, Tong JH, Mao M, Kan LX, Liu MM, Sun YW, Fu G, Jing YK, Yu L, Lepaslier D, Lanotte M, Wang ZY, Chen Z, Waxman S, Wang YX, Tan JZ, Chen SJ. Yu M, et al. Among authors: waxman s. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7406-11. doi: 10.1073/pnas.94.14.7406. Proc Natl Acad Sci U S A. 1997. PMID: 9207104 Free PMC article.
Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients.
Niu C, Yan H, Yu T, Sun HP, Liu JX, Li XS, Wu W, Zhang FQ, Chen Y, Zhou L, Li JM, Zeng XY, Yang RR, Yuan MM, Ren MY, Gu FY, Cao Q, Gu BW, Su XY, Chen GQ, Xiong SM, Zhang TD, Waxman S, Wang ZY, Chen Z, Hu J, Shen ZX, Chen SJ. Niu C, et al. Among authors: waxman s. Blood. 1999 Nov 15;94(10):3315-24. Blood. 1999. PMID: 10552940 Free article. Clinical Trial.
PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors.
Chen Z, Guidez F, Rousselot P, Agadir A, Chen SJ, Wang ZY, Degos L, Zelent A, Waxman S, Chomienne C. Chen Z, et al. Among authors: waxman s. Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):1178-82. doi: 10.1073/pnas.91.3.1178. Proc Natl Acad Sci U S A. 1994. PMID: 8302850 Free PMC article.
1,355 results