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SDZ RAD, a new rapamycin derivative: synergism with cyclosporine.
Schuurman HJ, Cottens S, Fuchs S, Joergensen J, Meerloo T, Sedrani R, Tanner M, Zenke G, Schuler W. Schuurman HJ, et al. Among authors: cottens s. Transplantation. 1997 Jul 15;64(1):32-5. doi: 10.1097/00007890-199707150-00007. Transplantation. 1997. PMID: 9233697
Chemical modification of rapamycin: the discovery of SDZ RAD.
Sedrani R, Cottens S, Kallen J, Schuler W. Sedrani R, et al. Among authors: cottens s. Transplant Proc. 1998 Aug;30(5):2192-4. doi: 10.1016/s0041-1345(98)00587-9. Transplant Proc. 1998. PMID: 9723437 No abstract available.
The immune modulator FTY720 targets sphingosine 1-phosphate receptors.
Brinkmann V, Davis MD, Heise CE, Albert R, Cottens S, Hof R, Bruns C, Prieschl E, Baumruker T, Hiestand P, Foster CA, Zollinger M, Lynch KR. Brinkmann V, et al. Among authors: cottens s. J Biol Chem. 2002 Jun 14;277(24):21453-7. doi: 10.1074/jbc.C200176200. Epub 2002 Apr 19. J Biol Chem. 2002. PMID: 11967257 Free article.
Structure-activity relationship and pharmacokinetic studies of sotrastaurin (AEB071), a promising novel medicine for prevention of graft rejection and treatment of psoriasis.
Wagner J, von Matt P, Faller B, Cooke NG, Albert R, Sedrani R, Wiegand H, Jean C, Beerli C, Weckbecker G, Evenou JP, Zenke G, Cottens S. Wagner J, et al. Among authors: cottens s. J Med Chem. 2011 Sep 8;54(17):6028-39. doi: 10.1021/jm200469u. Epub 2011 Aug 8. J Med Chem. 2011. PMID: 21797275
Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.
Wagner J, von Matt P, Sedrani R, Albert R, Cooke N, Ehrhardt C, Geiser M, Rummel G, Stark W, Strauss A, Cowan-Jacob SW, Beerli C, Weckbecker G, Evenou JP, Zenke G, Cottens S. Wagner J, et al. Among authors: cottens s. J Med Chem. 2009 Oct 22;52(20):6193-6. doi: 10.1021/jm901108b. J Med Chem. 2009. PMID: 19827831
18 results