Young LS - Search Results

1

Expression of the cellular FLICE-inhibitory protein (c-FLIP) protects Hodgkin's lymphoma cells from autonomous Fas-mediated death.

Dutton A, O'Neil JD, Milner AE, Reynolds GM, Starczynski J, Crocker J, Young LS, Murray PG. Dutton A, et al. Among authors: young ls. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6611-6. doi: 10.1073/pnas.0400765101. Epub 2004 Apr 19. Proc Natl Acad Sci U S A. 2004. PMID: 15096587 Free PMC article.

2

The role of cellular FLICE inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer.

Dutton A, Young LS, Murray PG. Dutton A, et al. Among authors: young ls. Expert Opin Ther Targets. 2006 Feb;10(1):27-35. doi: 10.1517/14728222.10.1.27. Expert Opin Ther Targets. 2006. PMID: 16441226 Review.

3

Targeting cellular FLICE-like inhibitory protein as a novel approach to the treatment of Hodgkin's lymphoma.

Dutton A, Burns AT, Young LS, Murray PG. Dutton A, et al. Among authors: young ls. Expert Rev Anticancer Ther. 2006 Jun;6(6):911-9. doi: 10.1586/14737140.6.6.911. Expert Rev Anticancer Ther. 2006. PMID: 16761935 Review.

4

Constitutive activation of phosphatidyl-inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving Akt kinase and mTOR.

Dutton A, Reynolds GM, Dawson CW, Young LS, Murray PG. Dutton A, et al. Among authors: young ls. J Pathol. 2005 Mar;205(4):498-506. doi: 10.1002/path.1725. J Pathol. 2005. PMID: 15714459

5

Bmi-1 is induced by the Epstein-Barr virus oncogene LMP1 and regulates the expression of viral target genes in Hodgkin lymphoma cells.

Dutton A, Woodman CB, Chukwuma MB, Last JI, Wei W, Vockerodt M, Baumforth KR, Flavell JR, Rowe M, Taylor AM, Young LS, Murray PG. Dutton A, et al. Among authors: young ls. Blood. 2007 Mar 15;109(6):2597-603. doi: 10.1182/blood-2006-05-020545. Epub 2006 Dec 5. Blood. 2007. PMID: 17148591 Free article.

6

Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells.

Flavell JR, Baumforth KR, Wood VH, Davies GL, Wei W, Reynolds GM, Morgan S, Boyce A, Kelly GL, Young LS, Murray PG. Flavell JR, et al. Among authors: young ls. Blood. 2008 Jan 1;111(1):292-301. doi: 10.1182/blood-2006-11-059881. Epub 2007 Aug 24. Blood. 2008. PMID: 17720884 Free article.

7

Expression of the Epstein-Barr virus-encoded Epstein-Barr virus nuclear antigen 1 in Hodgkin's lymphoma cells mediates Up-regulation of CCL20 and the migration of regulatory T cells.

Baumforth KR, Birgersdotter A, Reynolds GM, Wei W, Kapatai G, Flavell JR, Kalk E, Piper K, Lee S, Machado L, Hadley K, Sundblad A, Sjoberg J, Bjorkholm M, Porwit AA, Yap LF, Teo S, Grundy RG, Young LS, Ernberg I, Woodman CB, Murray PG. Baumforth KR, et al. Among authors: young ls. Am J Pathol. 2008 Jul;173(1):195-204. doi: 10.2353/ajpath.2008.070845. Epub 2008 May 23. Am J Pathol. 2008. PMID: 18502823 Free PMC article.

8

An etiological role for the Epstein-Barr virus in the pathogenesis of classical Hodgkin lymphoma.

Murray PG, Young LS. Murray PG, et al. Among authors: young ls. Blood. 2019 Aug 15;134(7):591-596. doi: 10.1182/blood.2019000568. Epub 2019 Jun 11. Blood. 2019. PMID: 31186275 Free article. Review.

9

Interleukin 6 expression by Hodgkin/Reed-Sternberg cells is associated with the presence of 'B' symptoms and failure to achieve complete remission in patients with advanced Hodgkin's disease.

Reynolds GM, Billingham LJ, Gray LJ, Flavell JR, Najafipour S, Crocker J, Nelson P, Young LS, Murray PG. Reynolds GM, et al. Among authors: young ls. Br J Haematol. 2002 Jul;118(1):195-201. doi: 10.1046/j.1365-2141.2002.03575.x. Br J Haematol. 2002. PMID: 12100148 Free article.

10

Inhibition of metalloproteinase cleavage enhances the cytotoxicity of Fas ligand.

Knox PG, Milner AE, Green NK, Eliopoulos AG, Young LS. Knox PG, et al. Among authors: young ls. J Immunol. 2003 Jan 15;170(2):677-85. doi: 10.4049/jimmunol.170.2.677. J Immunol. 2003. PMID: 12517928

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