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ErbB2 overexpression in human breast carcinoma is correlated with p21Cip1 up-regulation and tyrosine-15 hyperphosphorylation of p34Cdc2: poor responsiveness to chemotherapy with cyclophoshamide methotrexate, and 5-fluorouracil is associated with Erb2 overexpression and with p21Cip1 overexpression.
Yang W, Klos KS, Zhou X, Yao J, Yang Y, Smith TL, Shi D, Yu D. Yang W, et al. Among authors: zhou x. Cancer. 2003 Sep 15;98(6):1123-30. doi: 10.1002/cncr.11625. Cancer. 2003. PMID: 12973835 Free article.
Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis.
Li YM, Pan Y, Wei Y, Cheng X, Zhou BP, Tan M, Zhou X, Xia W, Hortobagyi GN, Yu D, Hung MC. Li YM, et al. Among authors: zhou x, zhou bp. Cancer Cell. 2004 Nov;6(5):459-69. doi: 10.1016/j.ccr.2004.09.027. Cancer Cell. 2004. PMID: 15542430 Free article.
ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells.
Klos KS, Wyszomierski SL, Sun M, Tan M, Zhou X, Li P, Yang W, Yin G, Hittelman WN, Yu D. Klos KS, et al. Among authors: zhou x. Cancer Res. 2006 Feb 15;66(4):2028-37. doi: 10.1158/0008-5472.CAN-04-4559. Cancer Res. 2006. PMID: 16489002 Free article.
14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition.
Lu J, Guo H, Treekitkarnmongkol W, Li P, Zhang J, Shi B, Ling C, Zhou X, Chen T, Chiao PJ, Feng X, Seewaldt VL, Muller WJ, Sahin A, Hung MC, Yu D. Lu J, et al. Among authors: zhou x. Cancer Cell. 2009 Sep 8;16(3):195-207. doi: 10.1016/j.ccr.2009.08.010. Cancer Cell. 2009. PMID: 19732720 Free PMC article.
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