Appel SH - Search Results

1

Epigallocatechin gallate prevents oxidative-stress-induced death of mutant Cu/Zn-superoxide dismutase (G93A) motoneuron cells by alteration of cell survival and death signals.

Koh SH, Kwon H, Kim KS, Kim J, Kim MH, Yu HJ, Kim M, Lee KW, Do BR, Jung HK, Yang KW, Appel SH, Kim SH. Koh SH, et al. Among authors: appel sh. Toxicology. 2004 Oct 1;202(3):213-25. doi: 10.1016/j.tox.2004.05.008. Toxicology. 2004. PMID: 15337584

2

PARP expression is increased in astrocytes but decreased in motor neurons in the spinal cord of sporadic ALS patients.

Kim SH, Henkel JS, Beers DR, Sengun IS, Simpson EP, Goodman JC, Engelhardt JI, Siklós L, Appel SH. Kim SH, et al. Among authors: appel sh. J Neuropathol Exp Neurol. 2003 Jan;62(1):88-103. doi: 10.1093/jnen/62.1.88. J Neuropathol Exp Neurol. 2003. PMID: 12528821

3

Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue.

Henkel JS, Engelhardt JI, Siklós L, Simpson EP, Kim SH, Pan T, Goodman JC, Siddique T, Beers DR, Appel SH. Henkel JS, et al. Among authors: appel sh. Ann Neurol. 2004 Feb;55(2):221-35. doi: 10.1002/ana.10805. Ann Neurol. 2004. PMID: 14755726

4

Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia.

Xiao Q, Zhao W, Beers DR, Yen AA, Xie W, Henkel JS, Appel SH. Xiao Q, et al. Among authors: appel sh. J Neurochem. 2007 Sep;102(6):2008-2019. doi: 10.1111/j.1471-4159.2007.04677.x. Epub 2007 Jun 7. J Neurochem. 2007. PMID: 17555556 Free article.

5

Extracellular mutant SOD1 induces microglial-mediated motoneuron injury.

Zhao W, Beers DR, Henkel JS, Zhang W, Urushitani M, Julien JP, Appel SH. Zhao W, et al. Among authors: appel sh. Glia. 2010 Jan 15;58(2):231-43. doi: 10.1002/glia.20919. Glia. 2010. PMID: 19672969 Free PMC article.

6

Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia.

Zhao W, Xie W, Xiao Q, Beers DR, Appel SH. Zhao W, et al. Among authors: appel sh. J Neurochem. 2006 Nov;99(4):1176-87. doi: 10.1111/j.1471-4159.2006.04172.x. Epub 2006 Oct 2. J Neurochem. 2006. PMID: 17018025 Free article.

7

Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis.

Beers DR, Henkel JS, Xiao Q, Zhao W, Wang J, Yen AA, Siklos L, McKercher SR, Appel SH. Beers DR, et al. Among authors: appel sh. Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):16021-6. doi: 10.1073/pnas.0607423103. Epub 2006 Oct 16. Proc Natl Acad Sci U S A. 2006. PMID: 17043238 Free PMC article.

8

Pyrimethamine significantly lowers cerebrospinal fluid Cu/Zn superoxide dismutase in amyotrophic lateral sclerosis patients with SOD1 mutations.

Lange DJ, Shahbazi M, Silani V, Ludolph AC, Weishaupt JH, Ajroud-Driss S, Fields KG, Remanan R, Appel SH, Morelli C, Doretti A, Maderna L, Messina S, Weiland U, Marklund SL, Andersen PM. Lange DJ, et al. Among authors: appel sh. Ann Neurol. 2017 Jun;81(6):837-848. doi: 10.1002/ana.24950. Epub 2017 Jun 9. Ann Neurol. 2017. PMID: 28480639 Free PMC article. Clinical Trial.

9

CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS.

Beers DR, Henkel JS, Zhao W, Wang J, Appel SH. Beers DR, et al. Among authors: appel sh. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15558-63. doi: 10.1073/pnas.0807419105. Epub 2008 Sep 22. Proc Natl Acad Sci U S A. 2008. PMID: 18809917 Free PMC article.

10

Mutant genes responsible for Parkinson's disease.

Le W, Appel SH. Le W, et al. Among authors: appel sh. Curr Opin Pharmacol. 2004 Feb;4(1):79-84. doi: 10.1016/j.coph.2003.09.005. Curr Opin Pharmacol. 2004. PMID: 15018843 Review.

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