Gentles R - Search Results

1

Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1.

Souers AJ, Wodka D, Gao J, Lewis JC, Vasudevan A, Gentles R, Brodjian S, Dayton B, Ogiela CA, Fry D, Hernandez LE, Marsh KC, Collins CA, Kym PR. Souers AJ, et al. Among authors: gentles r. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. doi: 10.1016/j.bmcl.2004.07.032. Bioorg Med Chem Lett. 2004. PMID: 15341942

2

Design, synthesis, and structural analysis of influenza neuraminidase inhibitors containing pyrrolidine cores.

Wang GT, Chen Y, Wang S, Gentles R, Sowin T, Kati W, Muchmore S, Giranda V, Stewart K, Sham H, Kempf D, Laver WG. Wang GT, et al. Among authors: gentles r. J Med Chem. 2001 Apr 12;44(8):1192-201. doi: 10.1021/jm000468c. J Med Chem. 2001. PMID: 11312919

3

Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 1.

Faghih R, Dwight W, Gentles R, Phelan K, Esbenshade TA, Ireland L, Miller TR, Kang CH, Fox GB, Gopalakrishnan SM, Hancock AA, Bennani YL. Faghih R, et al. Among authors: gentles r. Bioorg Med Chem Lett. 2002 Aug 5;12(15):2031-4. doi: 10.1016/s0960-894x(02)00309-8. Bioorg Med Chem Lett. 2002. PMID: 12113835

4

Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 2: binding preference for D-amino acids motifs.

Faghih R, Dwight W, Black L, Liu H, Gentles R, Phelan K, Esbenshade TA, Ireland L, Miller TR, Kang CH, Krueger KM, Fox GB, Hancock AA, Bennani YL. Faghih R, et al. Among authors: gentles r. Bioorg Med Chem Lett. 2002 Aug 5;12(15):2035-7. doi: 10.1016/s0960-894x(02)00310-4. Bioorg Med Chem Lett. 2002. PMID: 12113836

5

Standardization protocols and optimized precursor sets for the efficient application of automated parallel synthesis to lead optimization: a Mitsunobu example.

Gentles RG, Wodka D, Park DC, Vasudevan A. Gentles RG, et al. J Comb Chem. 2002 Sep-Oct;4(5):442-56. doi: 10.1021/cc010090j. J Comb Chem. 2002. PMID: 12217016

6

Synthesis and evaluation of potent pyrrolidine H(3) antagonists.

Vasudevan A, Conner SE, Gentles RG, Faghih R, Liu H, Dwight W, Ireland L, Kang CH, Esbenshade TA, Bennani YL, Hancock AA. Vasudevan A, et al. Among authors: gentles rg. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3055-8. doi: 10.1016/s0960-894x(02)00685-6. Bioorg Med Chem Lett. 2002. PMID: 12372500

7

Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core.

Wang GT, Wang S, Gentles R, Sowin T, Maring CJ, Kempf DJ, Kati WM, Stoll V, Stewart KD, Laver G. Wang GT, et al. Among authors: gentles r. Bioorg Med Chem Lett. 2005 Jan 3;15(1):125-8. doi: 10.1016/j.bmcl.2004.10.022. Bioorg Med Chem Lett. 2005. PMID: 15582424

8

Amino-substituted heterocycles as isosteres of trans-cinnamides: design and synthesis of heterocyclic biaryl sulfides as potent antagonists of LFA-1/ICAM-1 binding.

Wang GT, Wang S, Gentles R, Sowin T, Leitza S, Reilly EB, von Geldern TW. Wang GT, et al. Among authors: gentles r. Bioorg Med Chem Lett. 2005 Jan 3;15(1):195-201. doi: 10.1016/j.bmcl.2004.10.008. Bioorg Med Chem Lett. 2005. PMID: 15582439

9

Initial SAR studies on apamin-displacing 2-aminothiazole blockers of calcium-activated small conductance potassium channels.

Gentles RG, Grant-Young K, Hu S, Huang Y, Poss MA, Andres C, Fiedler T, Knox R, Lodge N, Weaver CD, Harden DG. Gentles RG, et al. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5316-9. doi: 10.1016/j.bmcl.2008.08.023. Epub 2008 Aug 14. Bioorg Med Chem Lett. 2008. PMID: 18774291

10

SAR studies on a series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides: potent inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus.

Gentles RG, Ding M, Zheng X, Chupak L, Poss MA, Beno BR, Pelosi L, Liu M, Lemm J, Wang YK, Roberts S, Gao M, Kadow J. Gentles RG, et al. Bioorg Med Chem Lett. 2011 May 15;21(10):3142-7. doi: 10.1016/j.bmcl.2011.03.008. Epub 2011 Mar 6. Bioorg Med Chem Lett. 2011. PMID: 21450465

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