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Pharmacological characterization and radioligand binding properties of a high-affinity, nonpeptide, bradykinin B1 receptor antagonist.
Ransom RW, Harrell CM, Reiss DR, Murphy KL, Chang RS, Hess JF, Miller PJ, O'Malley SS, Hey PJ, Kunapuli P, Su DS, Markowitz MK, Wallace MA, Raab CE, Jones AN, Dean DC, Pettibone DJ, Freidinger RM, Bock MG. Ransom RW, et al. Among authors: markowitz mk. Eur J Pharmacol. 2004 Sep 19;499(1-2):77-84. doi: 10.1016/j.ejphar.2004.07.104. Eur J Pharmacol. 2004. PMID: 15363953
Discovery of a potent, non-peptide bradykinin B1 receptor antagonist.
Su DS, Markowitz MK, DiPardo RM, Murphy KL, Harrell CM, O'Malley SS, Ransom RW, Chang RS, Ha S, Hess FJ, Pettibone DJ, Mason GS, Boyce S, Freidinger RM, Bock MG. Su DS, et al. Among authors: markowitz mk. J Am Chem Soc. 2003 Jun 25;125(25):7516-7. doi: 10.1021/ja0353457. J Am Chem Soc. 2003. PMID: 12812482
Generation and characterization of a human bradykinin receptor B1 transgenic rat as a pharmacodynamic model.
Hess JF, Ransom RW, Zeng Z, Chang RS, Hey PJ, Warren L, Harrell CM, Murphy KL, Chen TB, Miller PJ, Lis E, Reiss D, Gibson RE, Markowitz MK, DiPardo RM, Su DS, Bock MG, Gould RJ, Pettibone DJ. Hess JF, et al. Among authors: markowitz mk. J Pharmacol Exp Ther. 2004 Aug;310(2):488-97. doi: 10.1124/jpet.104.066886. Epub 2004 Mar 29. J Pharmacol Exp Ther. 2004. PMID: 15051800
Binding modes of dihydroquinoxalinones in a homology model of bradykinin receptor 1.
Ha SN, Hey PJ, Ransom RW, Harrell CM Jr, Murphy KL, Chang R, Chen TB, Su DS, Markowitz MK, Bock MG, Freidinger RM, Hess FJ. Ha SN, et al. Among authors: markowitz mk. Biochem Biophys Res Commun. 2005 May 27;331(1):159-66. doi: 10.1016/j.bbrc.2005.03.142. Biochem Biophys Res Commun. 2005. PMID: 15845373
Potent bradykinin B1 receptor antagonists: 4-substituted phenyl cyclohexanes.
Su DS, Lim JL, Markowitz MK, Wan BL, Murphy KL, Reiss DR, Harrell CM, O'Malley SS, Ransom RW, Chang RS, Pettibone DJ, Tang C, Prueksaritanont T, Freidinger RM, Bock MG. Su DS, et al. Among authors: markowitz mk. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3006-9. doi: 10.1016/j.bmcl.2007.03.059. Epub 2007 Mar 21. Bioorg Med Chem Lett. 2007. PMID: 17428657