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Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor.
Kodra JT, Jørgensen AS, Andersen B, Behrens C, Brand CL, Christensen IT, Guldbrandt M, Jeppesen CB, Knudsen LB, Madsen P, Nishimura E, Sams C, Sidelmann UG, Pedersen RA, Lynn FC, Lau J. Kodra JT, et al. Among authors: sidelmann ug. J Med Chem. 2008 Sep 11;51(17):5387-96. doi: 10.1021/jm7015599. Epub 2008 Aug 16. J Med Chem. 2008. PMID: 18707090
Optimization of alkylidene hydrazide based human glucagon receptor antagonists. Discovery of the highly potent and orally available 3-cyano-4-hydroxybenzoic acid [1-(2,3,5,6-tetramethylbenzyl)-1H-indol-4-ylmethylene]hydrazide.
Madsen P, Ling A, Plewe M, Sams CK, Knudsen LB, Sidelmann UG, Ynddal L, Brand CL, Andersen B, Murphy D, Teng M, Truesdale L, Kiel D, May J, Kuki A, Shi S, Johnson MD, Teston KA, Feng J, Lakis J, Anderes K, Gregor V, Lau J. Madsen P, et al. Among authors: sidelmann ug. J Med Chem. 2002 Dec 19;45(26):5755-75. doi: 10.1021/jm0208572. J Med Chem. 2002. PMID: 12477359
Small-molecule agonists for the glucagon-like peptide 1 receptor.
Knudsen LB, Kiel D, Teng M, Behrens C, Bhumralkar D, Kodra JT, Holst JJ, Jeppesen CB, Johnson MD, de Jong JC, Jorgensen AS, Kercher T, Kostrowicki J, Madsen P, Olesen PH, Petersen JS, Poulsen F, Sidelmann UG, Sturis J, Truesdale L, May J, Lau J. Knudsen LB, et al. Among authors: sidelmann ug. Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):937-42. doi: 10.1073/pnas.0605701104. Epub 2007 Jan 9. Proc Natl Acad Sci U S A. 2007. PMID: 17213325 Free PMC article.
Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project.
Lindon JC, Nicholson JK, Holmes E, Antti H, Bollard ME, Keun H, Beckonert O, Ebbels TM, Reily MD, Robertson D, Stevens GJ, Luke P, Breau AP, Cantor GH, Bible RH, Niederhauser U, Senn H, Schlotterbeck G, Sidelmann UG, Laursen SM, Tymiak A, Car BD, Lehman-McKeeman L, Colet JM, Loukaci A, Thomas C. Lindon JC, et al. Among authors: sidelmann ug. Toxicol Appl Pharmacol. 2003 Mar 15;187(3):137-46. doi: 10.1016/s0041-008x(02)00079-0. Toxicol Appl Pharmacol. 2003. PMID: 12662897
Large scale association analysis identifies three susceptibility loci for coronary artery disease.
Saade S, Cazier JB, Ghassibe-Sabbagh M, Youhanna S, Badro DA, Kamatani Y, Hager J, Yeretzian JS, El-Khazen G, Haber M, Salloum AK, Douaihy B, Othman R, Shasha N, Kabbani S, Bayeh HE, Chammas E, Farrall M, Gauguier D, Platt DE, Zalloua PA; FGENTCARD consortium. Saade S, et al. PLoS One. 2011;6(12):e29427. doi: 10.1371/journal.pone.0029427. Epub 2011 Dec 27. PLoS One. 2011. PMID: 22216278 Free PMC article.
27 results