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DUBbing down innate immunity.
Silverman N, Fitzgerald K. Silverman N, et al. Among authors: fitzgerald k. Nat Immunol. 2004 Oct;5(10):1010-2. doi: 10.1038/ni1004-1010. Nat Immunol. 2004. PMID: 15454928 No abstract available.
TOLLing away in Brazil.
Mitchell JA, Fitzgerald KA, Coyle A, Silverman N, Cartwright N. Mitchell JA, et al. Nat Immunol. 2006 Jul;7(7):675-9. doi: 10.1038/ni0706-675. Nat Immunol. 2006. PMID: 16785880 No abstract available.
Control of the innate immune response by the mevalonate pathway.
Akula MK, Shi M, Jiang Z, Foster CE, Miao D, Li AS, Zhang X, Gavin RM, Forde SD, Germain G, Carpenter S, Rosadini CV, Gritsman K, Chae JJ, Hampton R, Silverman N, Gravallese EM, Kagan JC, Fitzgerald KA, Kastner DL, Golenbock DT, Bergo MO, Wang D. Akula MK, et al. Among authors: fitzgerald ka. Nat Immunol. 2016 Aug;17(8):922-9. doi: 10.1038/ni.3487. Epub 2016 Jun 6. Nat Immunol. 2016. PMID: 27270400 Free PMC article.
Serine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling.
Paquette N, Conlon J, Sweet C, Rus F, Wilson L, Pereira A, Rosadini CV, Goutagny N, Weber AN, Lane WS, Shaffer SA, Maniatis S, Fitzgerald KA, Stuart L, Silverman N. Paquette N, et al. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12710-5. doi: 10.1073/pnas.1008203109. Epub 2012 Jul 16. Proc Natl Acad Sci U S A. 2012. PMID: 22802624 Free PMC article.
Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.
Weng D, Marty-Roix R, Ganesan S, Proulx MK, Vladimer GI, Kaiser WJ, Mocarski ES, Pouliot K, Chan FK, Kelliher MA, Harris PA, Bertin J, Gough PJ, Shayakhmetov DM, Goguen JD, Fitzgerald KA, Silverman N, Lien E. Weng D, et al. Among authors: fitzgerald ka. Proc Natl Acad Sci U S A. 2014 May 20;111(20):7391-6. doi: 10.1073/pnas.1403477111. Epub 2014 May 5. Proc Natl Acad Sci U S A. 2014. PMID: 24799678 Free PMC article.
Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner.
Bossaller L, Chiang PI, Schmidt-Lauber C, Ganesan S, Kaiser WJ, Rathinam VA, Mocarski ES, Subramanian D, Green DR, Silverman N, Fitzgerald KA, Marshak-Rothstein A, Latz E. Bossaller L, et al. Among authors: fitzgerald ka. J Immunol. 2012 Dec 15;189(12):5508-12. doi: 10.4049/jimmunol.1202121. Epub 2012 Nov 9. J Immunol. 2012. PMID: 23144495 Free PMC article.
Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1β production in response to β-glucans and the fungal pathogen, Candida albicans.
Ganesan S, Rathinam VAK, Bossaller L, Army K, Kaiser WJ, Mocarski ES, Dillon CP, Green DR, Mayadas TN, Levitz SM, Hise AG, Silverman N, Fitzgerald KA. Ganesan S, et al. Among authors: fitzgerald ka. J Immunol. 2014 Sep 1;193(5):2519-2530. doi: 10.4049/jimmunol.1400276. Epub 2014 Jul 25. J Immunol. 2014. PMID: 25063877 Free PMC article.
RNA and β-hemolysin of group B Streptococcus induce interleukin-1β (IL-1β) by activating NLRP3 inflammasomes in mouse macrophages.
Gupta R, Ghosh S, Monks B, DeOliveira RB, Tzeng TC, Kalantari P, Nandy A, Bhattacharjee B, Chan J, Ferreira F, Rathinam V, Sharma S, Lien E, Silverman N, Fitzgerald K, Firon A, Trieu-Cuot P, Henneke P, Golenbock DT. Gupta R, et al. Among authors: fitzgerald k. J Biol Chem. 2014 May 16;289(20):13701-5. doi: 10.1074/jbc.C114.548982. Epub 2014 Apr 1. J Biol Chem. 2014. PMID: 24692555 Free PMC article.
Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING.
Holm CK, Jensen SB, Jakobsen MR, Cheshenko N, Horan KA, Moeller HB, Gonzalez-Dosal R, Rasmussen SB, Christensen MH, Yarovinsky TO, Rixon FJ, Herold BC, Fitzgerald KA, Paludan SR. Holm CK, et al. Among authors: fitzgerald ka. Nat Immunol. 2012 Jun 17;13(8):737-43. doi: 10.1038/ni.2350. Nat Immunol. 2012. PMID: 22706339 Free PMC article.
IFI16 is an innate immune sensor for intracellular DNA.
Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S, Sirois CM, Jin T, Latz E, Xiao TS, Fitzgerald KA, Paludan SR, Bowie AG. Unterholzner L, et al. Nat Immunol. 2010 Nov;11(11):997-1004. doi: 10.1038/ni.1932. Epub 2010 Oct 3. Nat Immunol. 2010. PMID: 20890285 Free PMC article.
1,255 results