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Structurally simplified macrolactone analogues of halichondrin B.
Seletsky BM, Wang Y, Hawkins LD, Palme MH, Habgood GJ, DiPietro LV, Towle MJ, Salvato KA, Wels BF, Aalfs KK, Kishi Y, Littlefield BA, Yu MJ. Seletsky BM, et al. Among authors: wang y. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5547-50. doi: 10.1016/j.bmcl.2004.08.068. Bioorg Med Chem Lett. 2004. PMID: 15482921
Potent in vitro and in vivo anticancer activities of des-methyl, des-amino pateamine A, a synthetic analogue of marine natural product pateamine A.
Kuznetsov G, Xu Q, Rudolph-Owen L, Tendyke K, Liu J, Towle M, Zhao N, Marsh J, Agoulnik S, Twine N, Parent L, Chen Z, Shie JL, Jiang Y, Zhang H, Du H, Boivin R, Wang Y, Romo D, Littlefield BA. Kuznetsov G, et al. Among authors: wang y. Mol Cancer Ther. 2009 May;8(5):1250-60. doi: 10.1158/1535-7163.MCT-08-1026. Epub 2009 May 5. Mol Cancer Ther. 2009. PMID: 19417157 Free PMC article.
Discovery of anti-inflammatory clinical candidate E6201, inspired from resorcylic lactone LL-Z1640-2, III.
Shen Y, Boivin R, Yoneda N, Du H, Schiller S, Matsushima T, Goto M, Shirota H, Gusovsky F, Lemelin C, Jiang Y, Zhang Z, Pelletier R, Ikemori-Kawada M, Kawakami Y, Inoue A, Schnaderbeck M, Wang Y. Shen Y, et al. Among authors: wang y. Bioorg Med Chem Lett. 2010 May 15;20(10):3155-7. doi: 10.1016/j.bmcl.2010.03.087. Epub 2010 Mar 30. Bioorg Med Chem Lett. 2010. PMID: 20399648
Discovery of an in vitro and in vivo potent resorcylic lactone analog of LL-Z1640-2 as anti-inflammatory lead, II.
Shen Y, Du H, Kotake M, Matsushima T, Goto M, Shirota H, Gusovsky F, Li X, Jiang Y, Schiller S, Spyvee M, Davis H, Zhang Z, Pelletier R, Ikemori-Kawada M, Kawakami Y, Inoue A, Wang Y. Shen Y, et al. Among authors: wang y. Bioorg Med Chem Lett. 2010 May 15;20(10):3047-9. doi: 10.1016/j.bmcl.2010.03.119. Epub 2010 Apr 9. Bioorg Med Chem Lett. 2010. PMID: 20427182
E6201 [(3S,4R,5Z,8S,9S,11E)-14-(ethylamino)-8, 9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione], a novel kinase inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK)-1 and MEK kinase-1: in vitro characterization of its anti-inflammatory and antihyperproliferative activities.
Goto M, Chow J, Muramoto K, Chiba K, Yamamoto S, Fujita M, Obaishi H, Tai K, Mizui Y, Tanaka I, Young D, Yang H, Wang YJ, Shirota H, Gusovsky F. Goto M, et al. Among authors: wang yj. J Pharmacol Exp Ther. 2009 Nov;331(2):485-95. doi: 10.1124/jpet.109.156554. Epub 2009 Aug 14. J Pharmacol Exp Ther. 2009. PMID: 19684251
E6201, a novel kinase inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase-1 and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase-1: in vivo effects on cutaneous inflammatory responses by topical administration.
Muramoto K, Goto M, Inoue Y, Ishii N, Chiba K, Kuboi Y, Omae T, Wang YJ, Gusovsky F, Shirota H. Muramoto K, et al. Among authors: wang yj. J Pharmacol Exp Ther. 2010 Oct;335(1):23-31. doi: 10.1124/jpet.110.168583. Epub 2010 Jul 13. J Pharmacol Exp Ther. 2010. PMID: 20627998
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