Vermeulen NP - Search Results

1

Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism.

Keizers PH, Lussenburg BM, de Graaf C, Mentink LM, Vermeulen NP, Commandeur JN. Keizers PH, et al. Among authors: vermeulen np. Biochem Pharmacol. 2004 Dec 1;68(11):2263-71. doi: 10.1016/j.bcp.2004.08.013. Biochem Pharmacol. 2004. PMID: 15498516

2

Metabolism of N-substituted 7-methoxy-4-(aminomethyl) -coumarins by cytochrome P450 2D6 mutants and the indication of additional substrate interaction points.

Keizers PH, Van Dijk BR, De Graaf C, Van Vugt-Lussenburg BM, Vermeulen NP, Commandeur JN. Keizers PH, et al. Among authors: vermeulen np. Xenobiotica. 2006 Sep;36(9):763-71. doi: 10.1080/00498250600765325. Xenobiotica. 2006. PMID: 16971342

3

The role of phenylalanine 483 in cytochrome P450 2D6 is strongly substrate dependent.

Lussenburg BM, Keizers PH, de Graaf C, Hidestrand M, Ingelman-Sundberg M, Vermeulen NP, Commandeur JN. Lussenburg BM, et al. Among authors: vermeulen np. Biochem Pharmacol. 2005 Oct 15;70(8):1253-61. doi: 10.1016/j.bcp.2005.07.002. Biochem Pharmacol. 2005. PMID: 16135359

4

Metabolic regio- and stereoselectivity of cytochrome P450 2D6 towards 3,4-methylenedioxy-N-alkylamphetamines: in silico predictions and experimental validation.

Keizers PH, de Graaf C, de Kanter FJ, Oostenbrink C, Feenstra KA, Commandeur JN, Vermeulen NP. Keizers PH, et al. Among authors: vermeulen np. J Med Chem. 2005 Sep 22;48(19):6117-27. doi: 10.1021/jm050338+. J Med Chem. 2005. PMID: 16162012

5

Binding of 7-methoxy-4-(aminomethyl)-coumarin to wild-type and W128F mutant cytochrome P450 2D6 studied by time-resolved fluorescence spectroscopy.

Stortelder A, Keizers PH, Oostenbrink C, De Graaf C, De Kruijf P, Vermeulen NP, Gooijer C, Commandeur JN, Van der Zwan G. Stortelder A, et al. Among authors: vermeulen np. Biochem J. 2006 Feb 1;393(Pt 3):635-43. doi: 10.1042/BJ20051169. Biochem J. 2006. PMID: 16190863 Free PMC article.

6

Role of the conserved threonine 309 in mechanism of oxidation by cytochrome P450 2D6.

Keizers PH, Schraven LH, de Graaf C, Hidestrand M, Ingelman-Sundberg M, van Dijk BR, Vermeulen NP, Commandeur JN. Keizers PH, et al. Among authors: vermeulen np. Biochem Biophys Res Commun. 2005 Dec 16;338(2):1065-74. doi: 10.1016/j.bbrc.2005.10.066. Epub 2005 Oct 21. Biochem Biophys Res Commun. 2005. PMID: 16269134

7

Topological role of cytochrome P450 2D6 active site residues.

van Waterschoot RA, Keizers PH, de Graaf C, Vermeulen NP, Tschirret-Guth RA. van Waterschoot RA, et al. Among authors: vermeulen np. Arch Biochem Biophys. 2006 Mar 1;447(1):53-8. doi: 10.1016/j.abb.2006.01.002. Epub 2006 Jan 23. Arch Biochem Biophys. 2006. PMID: 16466686

8

Binding of bufuralol, dextromethorphan, and 3,4-methylenedioxymethylamphetamine to wild-type and F120A mutant cytochrome P450 2D6 studied by resonance Raman spectroscopy.

Bonifacio A, Keizers PH, Commandeur JN, Vermeulen NP, Robert B, Gooijer C, van der Zwan G. Bonifacio A, et al. Among authors: vermeulen np. Biochem Biophys Res Commun. 2006 May 12;343(3):772-9. doi: 10.1016/j.bbrc.2006.03.027. Epub 2006 Mar 20. Biochem Biophys Res Commun. 2006. PMID: 16563352

9

Catalytic site prediction and virtual screening of cytochrome P450 2D6 substrates by consideration of water and rescoring in automated docking.

de Graaf C, Oostenbrink C, Keizers PH, van der Wijst T, Jongejan A, Vermeulen NP. de Graaf C, et al. Among authors: vermeulen np. J Med Chem. 2006 Apr 20;49(8):2417-30. doi: 10.1021/jm0508538. J Med Chem. 2006. PMID: 16610785

10

Heterotropic and homotropic cooperativity by a drug-metabolising mutant of cytochrome P450 BM3.

van Vugt-Lussenburg BM, Damsten MC, Maasdijk DM, Vermeulen NP, Commandeur JN. van Vugt-Lussenburg BM, et al. Among authors: vermeulen np. Biochem Biophys Res Commun. 2006 Aug 4;346(3):810-8. doi: 10.1016/j.bbrc.2006.05.179. Epub 2006 Jun 8. Biochem Biophys Res Commun. 2006. PMID: 16777067

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