de Graaf C - Search Results

1

Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism.

Keizers PH, Lussenburg BM, de Graaf C, Mentink LM, Vermeulen NP, Commandeur JN. Keizers PH, et al. Among authors: de graaf c. Biochem Pharmacol. 2004 Dec 1;68(11):2263-71. doi: 10.1016/j.bcp.2004.08.013. Biochem Pharmacol. 2004. PMID: 15498516

2

Binding mode prediction of cytochrome p450 and thymidine kinase protein-ligand complexes by consideration of water and rescoring in automated docking.

de Graaf C, Pospisil P, Pos W, Folkers G, Vermeulen NP. de Graaf C, et al. J Med Chem. 2005 Apr 7;48(7):2308-18. doi: 10.1021/jm049650u. J Med Chem. 2005. PMID: 15801824 Free article.

3

Cytochrome p450 in silico: an integrative modeling approach.

de Graaf C, Vermeulen NP, Feenstra KA. de Graaf C, et al. J Med Chem. 2005 Apr 21;48(8):2725-55. doi: 10.1021/jm040180d. J Med Chem. 2005. PMID: 15828810 Review. No abstract available.

4

The role of phenylalanine 483 in cytochrome P450 2D6 is strongly substrate dependent.

Lussenburg BM, Keizers PH, de Graaf C, Hidestrand M, Ingelman-Sundberg M, Vermeulen NP, Commandeur JN. Lussenburg BM, et al. Among authors: de graaf c. Biochem Pharmacol. 2005 Oct 15;70(8):1253-61. doi: 10.1016/j.bcp.2005.07.002. Biochem Pharmacol. 2005. PMID: 16135359

5

Metabolic regio- and stereoselectivity of cytochrome P450 2D6 towards 3,4-methylenedioxy-N-alkylamphetamines: in silico predictions and experimental validation.

Keizers PH, de Graaf C, de Kanter FJ, Oostenbrink C, Feenstra KA, Commandeur JN, Vermeulen NP. Keizers PH, et al. Among authors: de kanter fj, de graaf c. J Med Chem. 2005 Sep 22;48(19):6117-27. doi: 10.1021/jm050338+. J Med Chem. 2005. PMID: 16162012

6

Binding of 7-methoxy-4-(aminomethyl)-coumarin to wild-type and W128F mutant cytochrome P450 2D6 studied by time-resolved fluorescence spectroscopy.

Stortelder A, Keizers PH, Oostenbrink C, De Graaf C, De Kruijf P, Vermeulen NP, Gooijer C, Commandeur JN, Van der Zwan G. Stortelder A, et al. Among authors: de kruijf p, de graaf c. Biochem J. 2006 Feb 1;393(Pt 3):635-43. doi: 10.1042/BJ20051169. Biochem J. 2006. PMID: 16190863 Free PMC article.

7

Role of the conserved threonine 309 in mechanism of oxidation by cytochrome P450 2D6.

Keizers PH, Schraven LH, de Graaf C, Hidestrand M, Ingelman-Sundberg M, van Dijk BR, Vermeulen NP, Commandeur JN. Keizers PH, et al. Among authors: de graaf c. Biochem Biophys Res Commun. 2005 Dec 16;338(2):1065-74. doi: 10.1016/j.bbrc.2005.10.066. Epub 2005 Oct 21. Biochem Biophys Res Commun. 2005. PMID: 16269134

8

The role and application of in silico docking in chemical genomics research.

Jongejan A, de Graaf C, Vermeulen NP, Leurs R, de Esch IJ. Jongejan A, et al. Among authors: de esch ij, de graaf c. Methods Mol Biol. 2005;310:63-91. doi: 10.1007/978-1-59259-948-6_5. Methods Mol Biol. 2005. PMID: 16350947

9

Topological role of cytochrome P450 2D6 active site residues.

van Waterschoot RA, Keizers PH, de Graaf C, Vermeulen NP, Tschirret-Guth RA. van Waterschoot RA, et al. Among authors: de graaf c. Arch Biochem Biophys. 2006 Mar 1;447(1):53-8. doi: 10.1016/j.abb.2006.01.002. Epub 2006 Jan 23. Arch Biochem Biophys. 2006. PMID: 16466686

10

Catalytic site prediction and virtual screening of cytochrome P450 2D6 substrates by consideration of water and rescoring in automated docking.

de Graaf C, Oostenbrink C, Keizers PH, van der Wijst T, Jongejan A, Vermeulen NP. de Graaf C, et al. J Med Chem. 2006 Apr 20;49(8):2417-30. doi: 10.1021/jm0508538. J Med Chem. 2006. PMID: 16610785

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