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Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor beta 1.
Gerwin BI, Spillare E, Forrester K, Lehman TA, Kispert J, Welsh JA, Pfeifer AM, Lechner JF, Baker SJ, Vogelstein B, et al. Gerwin BI, et al. Among authors: vogelstein b. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2759-63. doi: 10.1073/pnas.89.7.2759. Proc Natl Acad Sci U S A. 1992. PMID: 1557382 Free PMC article.
Mutant p53 proteins bind DNA abnormally in vitro.
Kern SE, Kinzler KW, Baker SJ, Nigro JM, Rotter V, Levine AJ, Friedman P, Prives C, Vogelstein B. Kern SE, et al. Among authors: vogelstein b. Oncogene. 1991 Jan;6(1):131-6. Oncogene. 1991. PMID: 1846954
p53 mutations in human cancers.
Hollstein M, Sidransky D, Vogelstein B, Harris CC. Hollstein M, et al. Among authors: vogelstein b. Science. 1991 Jul 5;253(5015):49-53. doi: 10.1126/science.1905840. Science. 1991. PMID: 1905840 Review.
p53 functions as a cell cycle control protein in osteosarcomas.
Diller L, Kassel J, Nelson CE, Gryka MA, Litwak G, Gebhardt M, Bressac B, Ozturk M, Baker SJ, Vogelstein B, et al. Diller L, et al. Among authors: vogelstein b. Mol Cell Biol. 1990 Nov;10(11):5772-81. doi: 10.1128/mcb.10.11.5772-5781.1990. Mol Cell Biol. 1990. PMID: 2233717 Free PMC article.
618 results