Ostroski R - Search Results

1

The discovery and preparation of disubstituted novel amino-aryl-piperidine-based renin inhibitors.

Cody WL, Holsworth DD, Powell NA, Jalaie M, Zhang E, Wang W, Samas B, Bryant J, Ostroski R, Ryan MJ, Edmunds JJ. Cody WL, et al. Among authors: ostroski r. Bioorg Med Chem. 2005 Jan 3;13(1):59-68. doi: 10.1016/j.bmc.2004.09.056. Bioorg Med Chem. 2005. PMID: 15582452

2

Discovery of novel non-peptidic ketopiperazine-based renin inhibitors.

Holsworth DD, Powell NA, Downing DM, Cai C, Cody WL, Ryan JM, Ostroski R, Jalaie M, Bryant JW, Edmunds JJ. Holsworth DD, et al. Among authors: ostroski r. Bioorg Med Chem. 2005 Apr 1;13(7):2657-64. doi: 10.1016/j.bmc.2005.01.048. Bioorg Med Chem. 2005. PMID: 15755665

3

Discovery of a series of imidazo[4,5-b]pyridines with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ.

Casimiro-Garcia A, Filzen GF, Flynn D, Bigge CF, Chen J, Davis JA, Dudley DA, Edmunds JJ, Esmaeil N, Geyer A, Heemstra RJ, Jalaie M, Ohren JF, Ostroski R, Ellis T, Schaum RP, Stoner C. Casimiro-Garcia A, et al. Among authors: ostroski r. J Med Chem. 2011 Jun 23;54(12):4219-33. doi: 10.1021/jm200409s. Epub 2011 May 26. J Med Chem. 2011. PMID: 21557540

4

A nonpeptide, piperidine renin inhibitor provides renal and cardiac protection in double-transgenic mice expressing human renin and angiotensinogen genes.

Major TC, Olszewski B, Rosebury W, Okerberg C, Carlson T, Ostroski R, Schroeder R, Kowala MC, Leadley R. Major TC, et al. Among authors: ostroski r. Cardiovasc Drugs Ther. 2008 Dec;22(6):469-78. doi: 10.1007/s10557-008-6131-x. Epub 2008 Aug 5. Cardiovasc Drugs Ther. 2008. PMID: 18679781

5

Pulmonary and cardiorenal cyclooxygenase-1 (COX-1), -2 (COX-2), and microsomal prostaglandin E synthase-1 (mPGES-1) and -2 (mPGES-2) expression in a hypertension model.

Radi ZA, Ostroski R. Radi ZA, et al. Among authors: ostroski r. Mediators Inflamm. 2007;2007:85091. doi: 10.1155/2007/85091. Mediators Inflamm. 2007. PMID: 17641732 Free PMC article.

6

Viral transduction of renin rapidly establishes persistent hypertension in diverse murine strains.

Harlan SM, Ostroski RA, Coskun T, Yantis LD, Breyer MD, Heuer JG. Harlan SM, et al. Among authors: ostroski ra. Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R467-74. doi: 10.1152/ajpregu.00106.2015. Epub 2015 Jun 24. Am J Physiol Regul Integr Comp Physiol. 2015. PMID: 26108870 Free article.

7

[No title available]

[No authors listed] [No authors listed] PMID: 31963071

8

Inosine reduces pain-related behavior in mice: involvement of adenosine A1 and A2A receptor subtypes and protein kinase C pathways.

Nascimento FP, Figueredo SM, Marcon R, Martins DF, Macedo SJ Jr, Lima DA, Almeida RC, Ostroski RM, Rodrigues AL, Santos AR. Nascimento FP, et al. Among authors: ostroski rm. J Pharmacol Exp Ther. 2010 Aug;334(2):590-8. doi: 10.1124/jpet.110.166058. Epub 2010 May 14. J Pharmacol Exp Ther. 2010. PMID: 20472668

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